Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.69 |
| ▸ | HTR1D | P28221 | 2/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | BAD | Q92934 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7932835 | 1.00 | HTR7 (0.69) | HTR7HTR1DCHRM3HTR1ACHRM2 | |
| Hydrochloric Acid SCHEMBL7926756 | 0.98 | HTR7 (0.67) | HTR7HTR1DCHRM3HTR1ACHRM2 | |
| SCHEMBL9727223 | 0.95 | HTR7 (0.71) | HTR7HTR1DCHRM3HTR1ACHRM2 | |
| SCHEMBL13533347 | 0.85 | HTR7 (0.66) | HTR7HTR1DCHRM3HTR1ACHRM2 | |
| SCHEMBL13533343 | 0.85 | HTR7 (0.70) | HTR7HTR1DCHRM3HTR1ACHRM2 | |
| SCHEMBL13533345 | 0.85 | HTR7 (0.66) | HTR7HTR1DCHRM3HTR1ACHRM2 | |
| SCHEMBL13533346 | 0.85 | HTR7 (0.70) | HTR7HTR1DCHRM3HTR1ACHRM2 | |
| SCHEMBL7935545 | 0.81 | HTR7 (0.51) | HTR7HTR1DHTR1A | |
| SCHEMBL7935409 | 0.80 | HTR1D (0.51) | HTR7HTR1DHTR1A | |
| SCHEMBL14591337 | 0.80 | HTR1D (0.51) | HTR7HTR1DHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4470990-A | 6,7,8,9-Tetrahydronaphtho(1,2-B)furan-8-amine derivatives and their use as dopamine receptor stimulants | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-09-11 | — | — | US | disclosed |