Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.71 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 3/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | BAD | Q92934 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11072209 | 0.95 | HTR7 (0.69) | HTR7CHRM3CHRM2CHRM1HTR1D | |
| SCHEMBL7932835 | 0.95 | HTR7 (0.69) | HTR7CHRM3CHRM2CHRM1HTR1D | |
| Hydrochloric Acid SCHEMBL7926756 | 0.94 | HTR7 (0.67) | HTR7CHRM3CHRM2CHRM1HTR1D | |
| SCHEMBL13533343 | 0.87 | HTR7 (0.70) | HTR7CHRM3CHRM2CHRM1HTR1D | |
| SCHEMBL13533347 | 0.87 | HTR7 (0.66) | HTR7CHRM3CHRM2CHRM1HTR1D | |
| SCHEMBL13533345 | 0.87 | HTR7 (0.66) | HTR7CHRM3CHRM2CHRM1HTR1D | |
| SCHEMBL13533346 | 0.87 | HTR7 (0.70) | HTR7CHRM3CHRM2CHRM1HTR1D | |
| SCHEMBL9727380 | 0.81 | HTR7 (0.60) | HTR7HTR1DHTR1ADRD2DRD3 | |
| SCHEMBL10554244 | 0.81 | HTR7 (0.70) | HTR7CHRM3CHRM2CHRM1HTR1D | |
| Hydrochloric Acid SCHEMBL7935442 | 0.80 | HTR7 (0.57) | HTR7CHRM3CHRM2CHRM1HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164385-A | AZETIDINE DERIVATIVES AND HYPOTENSIVE COMPOSITIONS THEREOF | JOHN WYETH & BROTHER, LTD. (GB) | 1992-11-17 | — | — | US | claimed |
| US-5164385-A | AZETIDINE DERIVATIVES AND HYPOTENSIVE COMPOSITIONS THEREOF | JOHN WYETH & BROTHER, LTD. (GB) | 1992-11-17 | — | — | US | disclosed |