Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11070189 | 0.89 | OPRL1 (0.43) | OPRL1OPRM1HRH3CYP2D6GRIN1 | |
| SCHEMBL11078406 | 0.88 | OPRL1 (0.51) | OPRL1OPRM1HRH3CYP2D6GRIN1 | |
| SCHEMBL11081934 | 0.81 | OPRL1 (0.51) | OPRL1OPRM1OPRK1MEN1KMT2A | |
| SCHEMBL11075825 | 0.79 | OPRM1 (0.51) | OPRL1OPRM1KDM4EMEN1LMNA | |
| SCHEMBL11073728 | 0.79 | OPRL1 (0.52) | OPRL1OPRM1HRH3CYP2D6GRIN1 | |
| SCHEMBL11076240 | 0.78 | OPRM1 (0.44) | OPRL1OPRM1OPRK1 | |
| Ethylbenzene SCHEMBL11070027 | 0.76 | OPRM1 (0.51) | OPRL1OPRM1 | |
| SCHEMBL11070148 | 0.75 | OPRL1 (0.49) | OPRL1OPRM1KMT2A | |
| SCHEMBL11075823 | 0.75 | OPRM1 (0.49) | OPRL1OPRM1 | |
| SCHEMBL11070020 | 0.75 | OPRM1 (0.49) | OPRL1OPRM1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4447454-A | Analgetic compounds, compositions and process of treatment | THE UPJOHN COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4113866-A | ANALGETIC COMPOUNDS, COMPOSITIONS AND PROCESS OF TREATMENT | THE UPJOHN COMPANY (US) | 1978-09-12 | — | — | US | disclosed |