Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078844 | 0.77 | TUBB1 (0.40) | KMT2AMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL11078320 | 0.77 | TUBB1 (0.44) | MAPTALDH1A1NPC1TUBB1TNFRSF1A | |
| SCHEMBL4864056 | 0.74 | TUBB1 (0.49) | KMT2AMAPTMEN1ALDH1A1TDP1 | |
| SCHEMBL29639206 | 0.71 | ESR1 (0.62) | KMT2AMAPTALDH1A1NPC1TUBB1 | |
| SCHEMBL1764953 | 0.71 | NPC1 (0.49) | KMT2AMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL21159215 | 0.70 | KMT2A (0.67) | KMT2AMAPTALDH1A1NPC1CES2 | |
| SCHEMBL6129273 | 0.69 | ABCG2 (0.51) | KMT2AMAPTMEN1ALDH1A1CES2 | |
| SCHEMBL728021 | 0.69 | ABCG2 (0.51) | KMT2AMAPTMEN1ALDH1A1CES2 | |
| SCHEMBL8146118 | 0.69 | TUBB1 (0.52) | KMT2AMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL10455751 | 0.68 | KMT2A (0.64) | KMT2AMAPTALDH1A1NPC1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0021000-B1 | SUBSTITUTED ACETOPHENONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-02-22 | — | — | EP | claimed |