SCHEMBL728021

SCHEMBL728021

COC(=Cc1ccccc1)C(=O)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 1/20 0.51
TSHR P16473 1/20 0.50
AKR1C1 Q04828 1/20 0.50
CES2 O00748 4/20 0.48
CES1 P23141 4/20 0.48
MTNR1A P48039 2/20 0.47
MTNR1B P49286 2/20 0.47
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
MAPT P10636 2/20 0.47
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47
POLB P06746 1/20 0.47
HPGD P15428 1/20 0.47
MAPK1 P28482 1/20 0.47
HTT P42858 1/20 0.47
AKR1C3 P42330 1/20 0.47
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6129273 1.00 ABCG2 (0.51) ABCG2TSHRAKR1C1CES2CES1
SCHEMBL9207327 0.85 ALDH1A1 (0.45) ABCG2CES2CES1MEN1KMT2A
SCHEMBL83065 0.84 AKR1C3 (0.55) ABCG2TSHRAKR1C1MEN1KMT2A
SCHEMBL3818255 0.84 AKR1C3 (0.55) ABCG2TSHRAKR1C1MEN1KMT2A
SCHEMBL3485765 0.84 AKR1C3 (0.55) ABCG2TSHRAKR1C1MEN1KMT2A
SCHEMBL9103420 0.84 ABCG2 (0.54) ABCG2TSHRAKR1C1MTNR1AMTNR1B
SCHEMBL5047540 0.82 RECQL (0.55) ABCG2TSHRMTNR1AMTNR1BMEN1
Hydrochloric Acid SCHEMBL10437231 0.82 AKR1C3 (0.53) ABCG2TSHRAKR1C1MEN1KMT2A
SCHEMBL1397476 0.82 ABCG2 (0.53) ABCG2TSHRMEN1KMT2AMAPT
SCHEMBL8351839 0.82 AKR1C3 (0.53) ABCG2TSHRAKR1C1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260013312-A1 PHOTOSENSITIVE ORGANIC INSULATING MATERIAL COMPOSITION, INSULATING FILM, GATE INSULATING FILM, TRANSISTOR, ELECTRONIC DEVICE, AND METHOD FOR MANUFACTURING TRANSISTOR NIKON CORPORATION (JP) 2026-01-08 US claimed
WO-2024189875-A1 PHOTOSENSITIVE ORGANIC INSULATING MATERIAL COMPOSITION, INSULATING FILM, GATE INSULATING FILM, TRANSISTOR, ELECTRONIC DEVICE, AND METHOD FOR MANUFACTURING TRANSISTOR 株式会社ニコン 2024-09-19 WO claimed
CN-114560993-B Preparation method of chalcone-terminated photosensitive waterborne polyurethane/epoxy acrylate 阜阳师范大学 2023-08-15 CN claimed
CN-115252655-B Probiotic metaplasia product for improving colpitis, preparation method and application 金华银河生物科技有限公司 2023-06-16 CN claimed
CN-115624517-A Probiotic metaplasia product and application thereof in promotion of skin health 内蒙古科拓生物有限公司 2023-01-20 CN claimed
CN-115252655-A Probiotic postbiotic product for improving vagina inflammation and preparation method and application thereof 金华银河生物科技有限公司 2022-11-01 CN claimed
US-20210347724-A1 METHOXYCHALCONE DERIVATIVES AND USES THEREOF THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2021-11-11 US claimed
CN-113105417-A Hydroxyl aurone derivative and preparation method and application thereof 中国科学院新疆理化技术研究所 2021-07-13 CN claimed
CN-104705565-A Method for preparing three-high (high blood lipid, high blood pressure and high blood sugar) prevention dietary therapy rice WANG YUEJIN 2015-06-17 CN claimed
EP-1534314-B1 A nutritional and therapeutic composition of an insulin sensitizer and a peptide fraction DSM IP ASSETS BV (NL) 2014-10-22 EP claimed
JP-4719465-B2 2011-07-06 JP claimed
US-7648957-B2 Nutritional and therapeutic composition of an insulin sensitizer and a peptide fraction DSM IP ASSETS B.V. (NL) 2010-01-19 US claimed
CN-101591230-A 2,4-dyhydroxyl chalcone derivative, Preparation Method And The Use TIANJIN INST PHARM RESEARCH (CN) 2009-12-02 CN claimed
JP-2006502154-A 2006-01-19 JP claimed
US-20050271744-A1 Nutritional and therapeutic composition of an insulin sensitizer and a peptide fraction DSM IP ASSETS B.V. (NL) 2005-12-08 US claimed
US-6903136-B2 Food supplements containing 4-hydroxyisoleucine and creatine EXPERIMENTAL AND APPLIED SCIENCES, INC. (US) 2005-06-07 US claimed
EP-1534314-A1 A NUTRITIONAL AND THERAPEUTIC COMPOSITION OF AN INSULIN SENSITIZER AND A PEPTIDE FRACTION DSM IP Assets B.V. (NL) 2005-06-01 EP claimed
WO-2004022083-A1 A NUTRITIONAL AND THERAPEUTIC COMPOSITION OF AN INSULIN SENSITIZER AND A PEPTIDE FRACTION DSM IP ASSETS B.V. (NL) 2004-03-18 WO claimed
US-20030224062-A1 Food supplements containing 4-hydroxyisoleucine and creatine NATIONAL SUPPLEMENT ASSOCIATION, INCORPORATED 2003-12-04 US claimed
WO-2003088947-A1 FOOD SUPPLEMENTS CONTAINING 4-HYDROXYISOLEUCINE AND CREATINE EXPERIMENTAL & APPLIED SCIENCES, INC. (US) 2003-10-30 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210347724-A1 METHOXYCHALCONE DERIVATIVES AND USES THEREOF MCL1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS ABCG2 145/4885TSHR 4831/4885AKR1C1 2867/4885
US-20260013312-A1 PHOTOSENSITIVE ORGANIC INSULATING MATERIAL COMPOSITION, INSULATING FILM, GATE INSULATING FILM, TRANSISTOR, ELECTRONIC DEVICE, AND METHOD FOR MANUFACTURING TRANSISTOR ICMT, PIGT, PORCN ABCG2 1328/4885TSHR 4657/4885AKR1C1 1041/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.