SCHEMBL4864056

SCHEMBL4864056

COC(=Cc1ccccc1)C(=O)c1ccc(OC)c(OC)c1OC

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB1 Q9H4B7 6/20 0.49
CYP1A1 P04798 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP1B1 Q16678 1/20 0.46
PKM P14618 1/20 0.46
MAPT P10636 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
NPC1 O15118 3/20 0.43
ALDH1A1 P00352 2/20 0.43
RAB9A P51151 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CASP3 P42574 1/20 0.43
SENP7 Q9BQF6 1/20 0.43
SENP6 Q9GZR1 1/20 0.43
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
POLB P06746 1/20 0.41
KDM4E B2RXH2 1/20 0.41
ABCG2 Q9UNQ0 1/20 0.41
TNFRSF1A P19438 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1764953 0.89 NPC1 (0.49) TUBB1MAPTNPC1ALDH1A1RAB9A
SCHEMBL8146118 0.89 TUBB1 (0.52) TUBB1MAPTNPC1ALDH1A1RAB9A
SCHEMBL8159031 0.83 TUBB1 (0.47) TUBB1CYP1A1CYP1A2CYP1B1PKM
SCHEMBL4535104 0.82 NPC1 (0.54) NPC1ALDH1A1RAB9APOLBABCG2
SCHEMBL9112546 0.80 ABCG2 (0.49) TUBB1MAPTNPC1ALDH1A1RAB9A
SCHEMBL6129286 0.80 CYP1A1 (0.45) TUBB1CYP1A1CYP1A2CYP1B1PKM
SCHEMBL11755939 0.79 CYP1A1 (0.46) TUBB1CYP1A1CYP1A2CYP1B1PKM
SCHEMBL11078320 0.77 TUBB1 (0.44) TUBB1PKMMAPTNPC1ALDH1A1
SCHEMBL11296303 0.76 SMN1; SMN2 (0.58) MAPTNPC1ALDH1A1RAB9AL3MBTL1
SCHEMBL27888985 0.76 MAPT (0.51) CYP1A2PKMMAPTTDP1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250255853-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2025-08-14 US disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20240285592-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2024-08-29 US disclosed
US-11951099-B2 Methods for treating plasma cell neoplasm with human therapeutic agents ANKH LIFE SCIENCES LIMITED (IE) 2024-04-09 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed
US-20220152001-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2022-05-19 US disclosed
US-11266634-B2 Methods for treating melanoma with human therapeutic agents ANKH LIFE SCIENCES LIMITED (IE) 2022-03-08 US disclosed
CN-113956226-A Method for synthesizing carvachin 南京科技职业学院 2022-01-21 CN disclosed
US-20200383958-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2020-12-10 US disclosed
US-10751330-B2 Human therapeutic agents ANKH LIFE SCIENCES LIMITED (IE) 2020-08-25 US disclosed
US-20180078535-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF IONS PHARMACEUTICAL S.À R.L. (LU) 2018-03-22 US disclosed
US-9907786-B2 Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof IONS PHARMACEUTICAL S.À R.L. (LU) 2018-03-06 US disclosed
US-20170216222-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF IONS PHARMACEUTICAL S.À R.L. (LU) 2017-08-03 US disclosed
US-20170105976-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF Ions Pharmaceutical S.à r.I. (LU) 2017-04-20 US disclosed
US-20170105975-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF IONS PHARMACEUTICAL S.À R.L. (LU) 2017-04-20 US disclosed
US-20170042867-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF IONS PHARMACEUTICAL S.À R.L. (LU) 2017-02-16 US disclosed
US-20170042865-A1 THERAPEUTIC COMPOSITIONS CONTAINING CURCUMIN, HARMINE, AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF IONS PHARMACEUTICAL S.À R.L. (LU) 2017-02-16 US disclosed
US-20170042866-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF IONS PHARMACEUTICAL S.À R.L. (LU) 2017-02-16 US disclosed
US-7432303-B2 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states Bowen, J. Phillip (US) 2008-10-07 US disclosed
US-20050148599-A1 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. 2005-07-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11266634-B2 Methods for treating melanoma with human therapeutic agents HNMT, INMT, TYR TUBB1 54/4885CYP1A1 3556/4885CYP1A2 3241/4885
US-20170216222-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, COMT TUBB1 124/4885CYP1A1 1827/4885CYP1A2 1507/4885
US-11951099-B2 Methods for treating plasma cell neoplasm with human therapeutic agents MCL1, CD44, INMT TUBB1 796/4885CYP1A1 3865/4885CYP1A2 3186/4885
US-20180078535-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, COMT TUBB1 124/4885CYP1A1 1827/4885CYP1A2 1507/4885
US-10751330-B2 Human therapeutic agents INMT, HNMT, HASPIN TUBB1 80/4885CYP1A1 2202/4885CYP1A2 2166/4885
US-20240285592-A1 HUMAN THERAPEUTIC AGENTS INMT, NLN, MYC TUBB1 116/4885CYP1A1 3142/4885CYP1A2 2789/4885
US-20170042865-A1 THERAPEUTIC COMPOSITIONS CONTAINING CURCUMIN, HARMINE, AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, CPT1A TUBB1 66/4885CYP1A1 1680/4885CYP1A2 1194/4885
US-20170105976-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, COMT TUBB1 124/4885CYP1A1 1827/4885CYP1A2 1507/4885
US-20170042867-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, COMT TUBB1 124/4885CYP1A1 1827/4885CYP1A2 1507/4885
US-20050148599-A1 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states FLT1, VEGFA, FLT4 TUBB1 1304/4885CYP1A1 625/4885CYP1A2 655/4885
US-20170042866-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, COMT TUBB1 124/4885CYP1A1 1827/4885CYP1A2 1507/4885
US-20220152001-A1 HUMAN THERAPEUTIC AGENTS INMT, HNMT, HASPIN TUBB1 80/4885CYP1A1 2202/4885CYP1A2 2166/4885
US-20170105975-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, COMT TUBB1 124/4885CYP1A1 1827/4885CYP1A2 1507/4885
US-20200383958-A1 HUMAN THERAPEUTIC AGENTS INMT, HNMT, HASPIN TUBB1 80/4885CYP1A1 2202/4885CYP1A2 2166/4885
US-20250255853-A1 HUMAN THERAPEUTIC AGENTS HASPIN, TIPARP, SHARPIN TUBB1 147/4885CYP1A1 4150/4885CYP1A2 4193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.