Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078482 | 0.89 | PDE3B (0.43) | PDE3BPDE3AKDM4EPDE5ALMNA | |
| SCHEMBL11067073 | 0.80 | ALDH1A1 (0.42) | PDE3BPDE3AKDM4ELMNAHPGD | |
| SCHEMBL11071485 | 0.73 | LRRK2 (0.39) | PDE3BPDE3AKDM4EPDE5ALMNA | |
| SCHEMBL11071741 | 0.73 | KDM4C (0.42) | PDE3BPDE3APDE5AHPGDKDM5A | |
| SCHEMBL7340847 | 0.71 | DYRK1A (0.49) | PDE3BPDE3AKDM4EPDE5ALMNA | |
| SCHEMBL11071637 | 0.70 | PDE3B (0.43) | PDE3BPDE3AKDM4EPDE5ALMNA | |
| SCHEMBL10816475 | 0.68 | DAO (0.59) | PDE3BPDE3AKDM4EPDE5ALMNA | |
| SCHEMBL28872678 | 0.68 | DAO (0.59) | PDE3BPDE3AKDM4EPDE5ALMNA | |
| SCHEMBL11071409 | 0.68 | PDE3B (0.43) | PDE3BPDE3AKDM4EPDE5ALMNA | |
| SCHEMBL11884982 | 0.66 | CYP2A6 (0.42) | CDK5DYRK1ACLK2CLK4DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4474786-A | CONGESTIVE HEART FAILURE | SCHERING CORPORATION (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |