Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 5/20 | 0.48 |
| ▸ | CLK2 | P49760 | 5/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM5C | P41229 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | CLK3 | P49761 | 4/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10816475 | 0.81 | DAO (0.59) | DYRK1ACLK1CLK2CLK4DYRK1B | |
| SCHEMBL7339595 | 0.80 | KDM4E (0.52) | DYRK1ACLK1KDM4ELMNAHPGD | |
| SCHEMBL7347264 | 0.78 | CDK4 (0.47) | CHUKPDE3BPDE3ALMNACYP2C19 | |
| SCHEMBL28872678 | 0.78 | DAO (0.59) | DYRK1ACHUKCLK1CLK2CLK4 | |
| SCHEMBL7339417 | 0.75 | PARP1 (0.47) | CDK5CDK5R1HTTPDE3BPDE3A | |
| SCHEMBL7348155 | 0.74 | DAO (0.44) | DYRK1ACHUKCLK1CLK2CLK4 | |
| SCHEMBL10134613 | 0.73 | CHUK (0.69) | CHUKCDK5CDK5R1KDM5AKDM5C | |
| SCHEMBL6432848 | 0.72 | PDE3A (0.55) | HTTPDE3BPDE3AKDM4EPDE5A | |
| SCHEMBL10964698 | 0.72 | DPYD (0.38) | PDE3BPDE3AKDM4EPDE5ALMNA | |
| SCHEMBL7338498 | 0.72 | PARP1 (0.47) | CDK5CDK5R1PDE3BPDE3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | claimed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | claimed |
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |