Sugi Predict

Sugi Predict / Compounds / SCHEMBL11076267

SCHEMBL11076267

SCHEMBL11076267

CCCCOC(=O)COC1CCCCO1

nearest known ligand 0.48

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.48
▸ KMT2A Q03164 1/20 0.48
▸ NAAA Q02083 1/20 0.40
▸ EPHX2 P34913 1/20 0.40
▸ RAB9A P51151 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ LMNA P02545 1/20 0.36
▸ POLB P06746 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21469084 0.91 KMT2A (0.44) MEN1KMT2AEPHX2RAB9AHSD17B10
SCHEMBL18296675 0.85 MEN1 (0.41) MEN1KMT2ANAAAEPHX2RAB9A
SCHEMBL374442 0.85 KMT2A (0.44) MEN1KMT2ARAB9ALMNAPOLB
SCHEMBL24172358 0.82 DGKA (0.51) MEN1KMT2ANAAAEPHX2
SCHEMBL8920889 0.82 DGKA (0.51) MEN1KMT2ANAAAEPHX2
SCHEMBL26695812 0.81 EPHX2 (0.46) MEN1KMT2ANAAAEPHX2LMNA
SCHEMBL4284988 0.80 KMT2A (0.42) MEN1KMT2ARAB9AHSD17B10LMNA
SCHEMBL2738489 0.80 MEN1 (0.51) MEN1KMT2ARAB9ASMN1; SMN2ALDH1A1
SCHEMBL11883324 0.80 ATM (0.53) MEN1KMT2ARAB9AHSD17B10
SCHEMBL11883318 0.80 ATM (0.53) MEN1KMT2ARAB9AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3774786-B1 METHOD FOR THE PREPARATION OF A 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONE BAYER AG (DE) 2024-12-25 — — EP disclosed
CN-112236426-B Process for preparing 2,4, 5-trisubstituted 1,2, 4-triazolones 拜耳股份有限公司 2024-07-05 — — CN disclosed
US-20230257362-A1 TRIAZOLONE COMPOUND MEDSHINE DISCOVERY INC. (CN) 2023-08-17 — — US disclosed
US-11365179-B2 Method for the preparation of a 2,4,5-trisubstituted 1,2,4-triazolone BAYER AKTIENGESELLSCHAFT (DE) 2022-06-21 — — US disclosed
US-11365179-B2 Method for the preparation of a 2,4,5-trisubstituted 1,2,4-triazolone BAYER AKTIENGESELLSCHAFT (DE) 2022-06-21 — — US disclosed
US-20210032212-A1 METHOD FOR THE PREPARATION OF A 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONE BAYER AKTIENGESELLSCHAFT (DE) 2021-02-04 — — US disclosed
WO-2019197239-A1 METHOD FOR THE PREPARATION OF A 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONE BAYER AKTIENGESELLSCHAFT (DE) 2019-10-17 — — WO disclosed
US-4427590-A Triazolobenzodiazepine derivatives CIBA-GEIGY CORPORATION (US) 1984-01-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230257362-A1 TRIAZOLONE COMPOUND WNK3, SLC10A1, WNK2 MEN1 1725/4885KMT2A 2247/4885NAAA 3478/4885
US-20210032212-A1 METHOD FOR THE PREPARATION OF A 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONE TES, CYP51A1, CYP4B1 MEN1 86/4885KMT2A 3495/4885NAAA 2742/4885
US-11365179-B2 Method for the preparation of a 2,4,5-trisubstituted 1,2,4-triazolone TES, CYP51A1, CYP4B1 MEN1 86/4885KMT2A 3495/4885NAAA 2742/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.