Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284988 | 0.95 | KMT2A (0.42) | KMT2AMEN1MGAMGAASI | |
| SCHEMBL20837278 | 0.88 | MGAM (0.39) | KMT2AMEN1MGAMGAASI | |
| SCHEMBL21469084 | 0.88 | KMT2A (0.44) | KMT2AMEN1GAAHPGDALDH1A1 | |
| SCHEMBL20548080 | 0.86 | KMT2A (0.41) | KMT2AMEN1CYP2D6CREBBPCYP1A2 | |
| SCHEMBL22071027 | 0.86 | KMT2A (0.49) | KMT2AMEN1LMNAPOLB | |
| SCHEMBL11076267 | 0.85 | MEN1 (0.48) | KMT2AMEN1LMNAPOLBALDH1A1 | |
| SCHEMBL25176578 | 0.84 | KMT2A (0.44) | KMT2AMEN1LMNAPOLBCYP1A2 | |
| SCHEMBL21068614 | 0.83 | KMT2A (0.47) | KMT2AMEN1 | |
| SCHEMBL9724933 | 0.83 | MEN1 (0.42) | KMT2AMEN1CREBBPHPGDALDH1A1 | |
| SCHEMBL8003850 | 0.82 | MEN1 (0.48) | KMT2AMEN1LMNAPOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3374350-B1 | HYDROXYPYRIDINONE AND HYDROXYPYRIMIDINONE BASED COMPOUNDS FOR TREATING BACTERIAL INFECTIONS | FORGE THERAPEUTICS INC (US) | 2022-01-05 | — | — | EP | disclosed |
| EP-3374350-B1 | HYDROXYPYRIDINONE AND HYDROXYPYRIMIDINONE BASED COMPOUNDS FOR TREATING BACTERIAL INFECTIONS | FORGE THERAPEUTICS INC (US) | 2022-01-05 | — | — | EP | disclosed |
| CN-107207476-B | Indole and azaindole derivatives and their use in neurodegenerative diseases | 默克专利有限公司 | 2021-03-19 | — | — | CN | disclosed |
| US-20210078957-A1 | SUBSTITUTED PYRIMIDINES FOR TREATING BACTERIAL INFECTIONS | FORGE THERAPEUTICS, INC. | 2021-03-18 | — | — | US | disclosed |
| US-20210078957-A1 | SUBSTITUTED PYRIMIDINES FOR TREATING BACTERIAL INFECTIONS | FORGE THERAPEUTICS, INC. | 2021-03-18 | — | — | US | disclosed |
| US-10875832-B2 | Substituted pyrimidines for treating bacterial infections | FORGE THERAPEUTICS, INC. (US) | 2020-12-29 | — | — | US | disclosed |
| US-10875832-B2 | Substituted pyrimidines for treating bacterial infections | FORGE THERAPEUTICS, INC. (US) | 2020-12-29 | — | — | US | disclosed |
| US-10676433-B2 | Indole derivatives and their use in neurodegenerative diseases | MERCK PATENT GMBH (DE) | 2020-06-09 | — | — | US | disclosed |
| US-10414735-B2 | Substituted hydroxypyrimidinones for treating bacterial infections | FORGE THERAPEUTICS, INC. (US) | 2019-09-17 | — | — | US | disclosed |
| US-10414735-B2 | Substituted hydroxypyrimidinones for treating bacterial infections | FORGE THERAPEUTICS, INC. (US) | 2019-09-17 | — | — | US | disclosed |
| WO-2007121453-A2 | 2-HYDROXY-1-OXO 1,2 DIHYDRO ISOQUINOLINE CHELATING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007116412-A1 | SUBSTITUTED PYRIMIDINES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS EFFECTIVE ABSORBENTS OF UV IRRADIATION | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED (IL) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |
| US-6846915-B2 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-01-25 | — | — | US | disclosed |
| US-20050008570-A1 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-01-13 | — | — | US | disclosed |
| US-20040220194-A1 | 2-Alkynyl-and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists | SCHERING CORPORATION | 2004-11-04 | — | — | US | disclosed |
| EP-1423399-A2 | HYDROXYPYRIDONATE AND HYDROXYPYRIMIDINONE CHELATING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-06-02 | — | — | EP | disclosed |
| US-20030095922-A1 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-05-22 | — | — | US | disclosed |
| WO-2003016923-A2 | HYDROXYPYRIDONATE AND HYDROXYPYRIMIDINONE CHELATING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-02-27 | — | — | WO | disclosed |
| US-3991053-A | GROWTH AND FEED EFFICIENCY PROMOTERS | PFIZER INC. (US) | 1976-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050008570-A1 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | HAMP, GDI1, MPI | KMT2A 2869/4885MEN1 843/4885MGAM 3286/4885 |
| US-20210078957-A1 | SUBSTITUTED PYRIMIDINES FOR TREATING BACTERIAL INFECTIONS | DPYD, TYMP, UMPS | KMT2A 2877/4885MEN1 3920/4885MGAM 1600/4885 |
| US-10414735-B2 | Substituted hydroxypyrimidinones for treating bacterial infections | ALPI, HPGDS, SDHB | KMT2A 3605/4885MEN1 3246/4885MGAM 604/4885 |
| US-20040220194-A1 | 2-Alkynyl-and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists | ADORA2A, ADORA3, ADORA1 | KMT2A 2995/4885MEN1 4658/4885MGAM 4835/4885 |
| US-10676433-B2 | Indole derivatives and their use in neurodegenerative diseases | P2RX3, ADORA2A, P2RX7 | KMT2A 2560/4885MEN1 4055/4885MGAM 3794/4885 |
| US-10875832-B2 | Substituted pyrimidines for treating bacterial infections | UMPS, DPYD, TYMP | KMT2A 2762/4885MEN1 4518/4885MGAM 2090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.