Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.71 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | PDE4A | P27815 | 2/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | PDE5A | O76074 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | CCNC | P24863 | 1/20 | 0.55 |
| ▸ | CDK8 | P49336 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11234713 | 0.83 | PDE3B (0.67) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11235286 | 0.83 | PDE3B (1.00) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11235848 | 0.83 | PDE3B (0.67) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11291892 | 0.83 | PDE3B (0.67) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11236528 | 0.80 | PDE3B (0.63) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11235919 | 0.80 | PDE3B (0.63) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11106121 | 0.80 | PDE3B (0.66) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11291385 | 0.80 | PDE3B (0.63) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11080306 | 0.80 | PDE3B (0.48) | PDE3BPDE3AAURKBINCENPKDM4E | |
| Milrinone SCHEMBL9247989 | 0.79 | PDE3A (1.00) | PDE3BPDE3AAURKBINCENPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109628-A1 | 2(1H)-pyridinones and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1984-05-30 | — | — | EP | claimed |
| EP-0109628-A1 | 2(1H)-pyridinones and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1984-05-30 | — | — | EP | disclosed |