Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 12/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.63 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.63 |
| ▸ | PDE4A | P27815 | 2/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | PDE5A | O76074 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | CCNC | P24863 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11291892 | 0.81 | PDE3B (0.67) | PDE3BPDE3AAURKBINCENPPDE4A | |
| SCHEMBL11076607 | 0.80 | PDE3B (0.71) | PDE3BPDE3AAURKBINCENPPDE4A | |
| SCHEMBL11235848 | 0.78 | PDE3B (0.67) | PDE3BPDE3AAURKBINCENPPDE4A | |
| SCHEMBL11235286 | 0.78 | PDE3B (1.00) | PDE3BPDE3AAURKBINCENPPDE4A | |
| SCHEMBL11234713 | 0.78 | PDE3B (0.67) | PDE3BPDE3AAURKBINCENPPDE4A | |
| SCHEMBL12211637 | 0.77 | PDE3B (0.61) | PDE3BPDE3AAURKBINCENPPDE4A | |
| SCHEMBL11234900 | 0.77 | PDE3B (0.61) | PDE3BPDE3AAURKBINCENPPDE4A | |
| SCHEMBL24334610 | 0.76 | PDE3B (0.60) | PDE3BPDE3AAURKBINCENPPDE4A | |
| SCHEMBL10704473 | 0.76 | CCNC (0.67) | PDE3BPDE3AAURKBINCENPPDE4A | |
| SCHEMBL5902068 | 0.76 | CDK5 (0.66) | CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361569-A | 3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone and cardiotonic use thereof | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | claimed |
| US-4361569-A | 3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone and cardiotonic use thereof | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| US-4361569-A | 3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone and cardiotonic use thereof | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |