Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 11/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11241034 | 0.83 | PDE3B (0.66) | PDE3BPDE3AAURKBINCENPCDK5 | |
| SCHEMBL11236260 | 0.83 | PDE3B (0.43) | PDE3BPDE3AAURKBINCENPCDK5 | |
| SCHEMBL11251979 | 0.81 | PDE3B (0.42) | PDE3BPDE3AAURKBINCENPCDK5 | |
| SCHEMBL11076607 | 0.80 | PDE3B (0.71) | PDE3BPDE3AAURKBINCENPKDM4E | |
| SCHEMBL11231010 | 0.80 | PDE3A (0.68) | PDE3BPDE3AAURKBINCENPCDK5 | |
| SCHEMBL11238710 | 0.80 | CDK5 (0.49) | PDE3BPDE3AAURKBINCENPCDK5 | |
| SCHEMBL11246267 | 0.79 | PDE3B (0.40) | PDE3BPDE3AAURKBINCENPCDK5 | |
| SCHEMBL11246751 | 0.79 | CDC7 (0.61) | PDE3BPDE3AAURKBINCENPCDK5 | |
| SCHEMBL11223807 | 0.76 | CDK5 (0.44) | PDE3BPDE3AAURKBINCENPCDK5 | |
| SCHEMBL8334066 | 0.76 | CDK5 (0.68) | CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109628-A1 | 2(1H)-pyridinones and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1984-05-30 | — | — | EP | disclosed |