Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 3/20 | 0.36 |
| ▸ | IGF1R | P08069 | 3/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078536 | 0.85 | OPRL1 (0.42) | OPRL1L3MBTL1MAPTSLC6A4SLC6A3 | |
| SCHEMBL11070850 | 0.80 | OPRL1 (0.53) | OPRL1L3MBTL1OPRM1HTR2ASLC6A2 | |
| SCHEMBL11071725 | 0.80 | OPRL1 (0.37) | OPRL1OPRM1SLC6A4SLC6A3 | |
| SCHEMBL11066053 | 0.77 | OPRL1 (0.49) | OPRL1OPRM1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL11078293 | 0.75 | OPRL1 (0.56) | OPRL1L3MBTL1OPRM1RAB9ADUSP3 | |
| SCHEMBL11071655 | 0.75 | SLC6A4 (0.53) | OPRL1L3MBTL1MAPTOPRM1KMT2A | |
| SCHEMBL11071653 | 0.74 | MAPK1 (0.40) | OPRL1L3MBTL1OPRM1KMT2ASLC6A2 | |
| SCHEMBL11077290 | 0.73 | OPRD1 (0.55) | OPRL1OPRM1 | |
| SCHEMBL11073750 | 0.72 | OPRL1 (0.50) | OPRL1ACVR1OPRM1DUSP3KMT2A | |
| SCHEMBL11066279 | 0.72 | SLC6A4 (0.41) | OPRL1L3MBTL1MAPTOPRM1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4447454-A | Analgetic compounds, compositions and process of treatment | THE UPJOHN COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4113866-A | ANALGETIC COMPOUNDS, COMPOSITIONS AND PROCESS OF TREATMENT | THE UPJOHN COMPANY (US) | 1978-09-12 | — | — | US | disclosed |