Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPSE | Q9Y251 | 5/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11066087 | 0.90 | KMT2A (0.43) | KMT2AMEN1MAPTALDH1A1HPSE | |
| SCHEMBL11071981 | 0.89 | PDE5A (0.41) | KMT2AMEN1NPC1RAB9ARXFP1 | |
| SCHEMBL11065268 | 0.88 | CYP2C9 (0.44) | KMT2AMEN1MAPTHPSECHEK2 | |
| SCHEMBL10742473 | 0.86 | MAPT (0.42) | KMT2AMAPTHPSECHEK2 | |
| SCHEMBL10763240 | 0.83 | CDK4 (0.45) | KMT2AMEN1NPC1RAB9ACDK4 | |
| SCHEMBL11074215 | 0.83 | HPSE (0.39) | KMT2AMAPTHPSE | |
| SCHEMBL10765896 | 0.82 | ATR (0.48) | KMT2AMEN1NPC1RAB9ACDK4 | |
| SCHEMBL10765238 | 0.82 | CDK4 (0.45) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL11065296 | 0.81 | PDE5A (0.38) | KMT2AMAPTHPSE | |
| SCHEMBL10762025 | 0.80 | CDK4 (0.59) | CDK4CCNA2CCND1CDK2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |