Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | HPSE | Q9Y251 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11061395 | 0.93 | PDE5A (0.39) | PDE5AHPSEMAPTKMT2AKDR | |
| SCHEMBL11074215 | 0.90 | HPSE (0.39) | PDE5AHPSEMAPTKMT2AADORA2A | |
| SCHEMBL11071306 | 0.83 | PDE5A (0.40) | PDE5AHPSEMAPTKMT2ATP53 | |
| SCHEMBL11066087 | 0.83 | KMT2A (0.43) | PDE5AHPSEMAPTKMT2A | |
| SCHEMBL11076891 | 0.81 | KMT2A (0.44) | HPSEMAPTKMT2A | |
| SCHEMBL11065268 | 0.81 | CYP2C9 (0.44) | PDE5AHPSEMAPTKMT2A | |
| SCHEMBL10767330 | 0.78 | MAPK10 (0.39) | PDE5A | |
| SCHEMBL10742473 | 0.77 | MAPT (0.42) | HPSEMAPTKMT2A | |
| SCHEMBL7270954 | 0.76 | PDE5A (0.48) | PDE5AKMT2A | |
| SCHEMBL10738053 | 0.76 | PDE5A (0.45) | PDE5AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |