Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 2/20 | 0.37 |
| ▸ | PLAU | P00749 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11076891 | 0.89 | KMT2A (0.44) | KMT2AMEN1NPC1RAB9ARXFP1 | |
| SCHEMBL11071306 | 0.84 | PDE5A (0.40) | PDE5AKMT2AMEN1HPSEMAPT | |
| SCHEMBL11066087 | 0.84 | KMT2A (0.43) | PDE5AKMT2AMEN1HPSEMAPT | |
| SCHEMBL11065268 | 0.81 | CYP2C9 (0.44) | PDE5AKMT2AMEN1HPSEMAPT | |
| SCHEMBL11022213 | 0.79 | ATR (0.44) | PDE5AMAPT | |
| SCHEMBL10742473 | 0.76 | MAPT (0.42) | KMT2AHPSEMAPTPLAU | |
| SCHEMBL11065296 | 0.75 | PDE5A (0.38) | PDE5AKMT2AHPSEMAPTTP53 | |
| Hydrochloric Acid SCHEMBL11353296 | 0.74 | GUSB (0.38) | PDE5AKMT2ARXFP1 | |
| SCHEMBL11061395 | 0.73 | PDE5A (0.39) | PDE5AKMT2AHPSEMAPT | |
| SCHEMBL11074215 | 0.73 | HPSE (0.39) | PDE5AKMT2AHPSEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |