SCHEMBL11076895

SCHEMBL11076895

CCOc1nccc(N)n1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 1/20 0.47
ALOX5AP P20292 5/20 0.42
FEN1 P39748 5/20 0.42
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
MAPK8 P45983 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
LMNA P02545 1/20 0.40
NOS3 P29474 2/20 0.39
NOS1 P29475 2/20 0.39
NOS2 P35228 2/20 0.39
RXRA P19793 4/20 0.39
GRIN1 Q05586 4/20 0.39
GRIN2B Q13224 4/20 0.39
TSHR P16473 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
ACACB O00763 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17767985 0.84 MCHR1 (0.46) SCN9AALOX5APFEN1NPC1RAB9A
SCHEMBL16631778 0.82 MCHR1 (0.47) SCN9AALOX5APFEN1NPC1RAB9A
SCHEMBL28311237 0.79 SCN9A (0.47) SCN9AALOX5APFEN1NOS3NOS1
SCHEMBL27773474 0.79 SCN9A (0.51) SCN9AALOX5APFEN1NOS3NOS1
SCHEMBL14880376 0.79 SCN9A (0.44) SCN9AALOX5APFEN1NOS3NOS1
SCHEMBL30842078 0.78
SCHEMBL331710 0.78
SCHEMBL16357824 0.78 NOS3 (0.44) SCN9AALOX5APFEN1NPC1RAB9A
SCHEMBL30278077 0.77 SCN9A (0.42) SCN9AALOX5APFEN1SMN1; SMN2NOS3
SCHEMBL19015184 0.77 SCN9A (0.40) SCN9AALOX5APFEN1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4097138-A1 ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS Avila Therapeutics, Inc. (US) 2022-12-07 EP disclosed
WO-2021155317-A1 ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS AVILAR THERAPEUTICS, INC. (US) 2021-08-05 WO disclosed
EP-2768509-B1 SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS GLAXOSMITHKLINE LLC (US) 2017-03-22 EP disclosed
US-4447609-A Method of preparing 2-alkoxy-4-aminopyrimidines DYNAMIT NOBEL AG (DE) 1984-05-08 US disclosed
EP-0061019-A1 Method for the preparation of 2-alkoxy-4-aminopyrimidines HÜLS TROISDORF AKTIENGESELLSCHAFT (DE) 1982-09-29 EP disclosed