Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.58 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | QPCT | Q16769 | 4/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078037 | 1.00 | TUBB1 (0.58) | TUBB1TBXAS1ALDH1A1MAPTHPGD | |
| SCHEMBL11077563 | 0.85 | TUBB1 (0.59) | TUBB1TBXAS1ALDH1A1QPCTCYP1A1 | |
| SCHEMBL11077568 | 0.85 | TUBB1 (0.59) | TUBB1TBXAS1ALDH1A1QPCTCYP1A1 | |
| SCHEMBL6963677 | 0.83 | CYP19A1 (0.60) | TUBB1TBXAS1ALDH1A1 | |
| SCHEMBL6963682 | 0.83 | CYP19A1 (0.60) | TUBB1TBXAS1ALDH1A1 | |
| SCHEMBL11080818 | 0.79 | TBXAS1 (0.57) | TUBB1TBXAS1CYP1A2CYP2D6POLB | |
| SCHEMBL11080822 | 0.79 | TBXAS1 (0.57) | TUBB1TBXAS1CYP1A2CYP2D6POLB | |
| SCHEMBL11077393 | 0.77 | KDM4E (0.51) | TBXAS1ALDH1A1SMN1; SMN2CYP1A1CYP1B1 | |
| SCHEMBL11077391 | 0.77 | KDM4E (0.51) | TBXAS1ALDH1A1SMN1; SMN2CYP1A1CYP1B1 | |
| SCHEMBL11390231 | 0.75 | TBXAS1 (0.53) | TBXAS1ALDH1A1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4396771-A | THROMBOEMBOLIC DISORDERS, SHOCK | BURROUGHS WELLCOME CO. (US) | 1983-08-02 | — | — | US | claimed |
| US-4431815-A | CARDIOTONIC AND ANTISHOCK AGENTS; ANTICOAGULANTS | BURROUGHS WELLCOME CO. (US) | 1984-02-14 | — | — | US | disclosed |
| US-4425354-A | CARDIOVASCULAR DISORDERS | BURROUGHS WELLCOME CO. (US) | 1984-01-10 | — | — | US | disclosed |
| EP-0003732-B1 | IMIDAZOLE DERIVATIVES AND SALTS THEREOF, THEIR SYNTHESIS, AND PHARMACEUTICAL FORMULATIONS THEREOF | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-10-19 | — | — | EP | disclosed |
| US-4405634-A | Imidazole derivatives for treating myocardial infarction | BURROUGHS WELLCOME CO. (US) | 1983-09-20 | — | — | US | disclosed |
| US-4396771-A | THROMBOEMBOLIC DISORDERS, SHOCK | BURROUGHS WELLCOME CO. (US) | 1983-08-02 | — | — | US | disclosed |
| US-4357340-A | Imidazole derivatives and angina pectoris | BURROUGHS WELLCOME CO. (US) | 1982-11-02 | — | — | US | disclosed |