Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080822 | 1.00 | TBXAS1 (0.57) | TBXAS1HTTCYP11B1CYP11B2PSEN1 | |
| SCHEMBL11078035 | 0.79 | TUBB1 (0.58) | TBXAS1POLBTUBB1CYP1A2CYP2D6 | |
| SCHEMBL11078037 | 0.79 | TUBB1 (0.58) | TBXAS1POLBTUBB1CYP1A2CYP2D6 | |
| SCHEMBL6954397 | 0.78 | TBXAS1 (0.56) | TBXAS1CYP11B1CYP11B2POLBCYP19A1 | |
| SCHEMBL6954390 | 0.78 | TBXAS1 (0.56) | TBXAS1CYP11B1CYP11B2POLBCYP19A1 | |
| SCHEMBL6963682 | 0.78 | CYP19A1 (0.60) | TBXAS1CYP11B1CYP11B2CYP19A1TUBB1 | |
| SCHEMBL6963677 | 0.78 | CYP19A1 (0.60) | TBXAS1CYP11B1CYP11B2CYP19A1TUBB1 | |
| SCHEMBL11078989 | 0.77 | TBXAS1 (0.65) | TBXAS1CYP11B1CYP11B2CYP19A1TSHR | |
| SCHEMBL11078987 | 0.77 | TBXAS1 (0.65) | TBXAS1CYP11B1CYP11B2CYP19A1TSHR | |
| SCHEMBL11378232 | 0.77 | TBXAS1 (0.60) | TBXAS1TSHRCYP1A2USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4396771-A | THROMBOEMBOLIC DISORDERS, SHOCK | BURROUGHS WELLCOME CO. (US) | 1983-08-02 | — | — | US | claimed |
| US-4357340-A | Imidazole derivatives and angina pectoris | BURROUGHS WELLCOME CO. (US) | 1982-11-02 | — | — | US | claimed |
| US-4431815-A | CARDIOTONIC AND ANTISHOCK AGENTS; ANTICOAGULANTS | BURROUGHS WELLCOME CO. (US) | 1984-02-14 | — | — | US | disclosed |
| US-4425354-A | CARDIOVASCULAR DISORDERS | BURROUGHS WELLCOME CO. (US) | 1984-01-10 | — | — | US | disclosed |
| EP-0003732-B1 | IMIDAZOLE DERIVATIVES AND SALTS THEREOF, THEIR SYNTHESIS, AND PHARMACEUTICAL FORMULATIONS THEREOF | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-10-19 | — | — | EP | disclosed |
| US-4405634-A | Imidazole derivatives for treating myocardial infarction | BURROUGHS WELLCOME CO. (US) | 1983-09-20 | — | — | US | disclosed |
| US-4396771-A | THROMBOEMBOLIC DISORDERS, SHOCK | BURROUGHS WELLCOME CO. (US) | 1983-08-02 | — | — | US | disclosed |
| US-4357340-A | Imidazole derivatives and angina pectoris | BURROUGHS WELLCOME CO. (US) | 1982-11-02 | — | — | US | disclosed |