Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 3/20 | 0.57 |
| ▸ | ODC1 | P11926 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | ARG1 | P05089 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11081595 | 1.00 | BLM (0.57) | BLMODC1SLC7A5SMN1; SMN2KDM4E | |
| SCHEMBL22074778 | 0.87 | BLM (0.58) | BLMSLC7A5SMN1; SMN2KDM4EMAPT | |
| SCHEMBL1274884 | 0.86 | SMN1; SMN2 (0.58) | BLMODC1SLC7A5SMN1; SMN2KDM4E | |
| SCHEMBL1274883 | 0.86 | SMN1; SMN2 (0.58) | BLMODC1SLC7A5SMN1; SMN2KDM4E | |
| SCHEMBL25578518 | 0.85 | BLM (0.51) | BLMSLC7A5KDM4EESR1CA2 | |
| SCHEMBL6718873 | 0.82 | KDM4E (0.60) | BLMODC1SLC7A5SMN1; SMN2KDM4E | |
| SCHEMBL11574844 | 0.82 | KDM4E (0.60) | BLMODC1SLC7A5SMN1; SMN2KDM4E | |
| SCHEMBL11084247 | 0.81 | GRM2 (0.44) | BLMODC1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL11493903 | 0.79 | BLM (0.57) | BLMSLC7A5SMN1; SMN2KDM4EMAPT | |
| SCHEMBL11493907 | 0.79 | BLM (0.57) | BLMSLC7A5SMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174460-A1 | AFMT ANALOGS AND THEIR USE IN METHODS OF TREATING PARKINSON'S DISEASE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2023-06-08 | — | — | US | disclosed |
| US-4483870-A | α-Difluoromethyl amino acids and hypertension treating compositions thereof | MERCK & CO., INC. (US) | 1984-11-20 | — | — | US | disclosed |
| EP-0007600-B1 | ALPHA-DIFLUOROMETHYL AMINO ACIDS AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1983-05-11 | — | — | EP | disclosed |
| EP-0007600-A1 | Alpha-difluoromethyl amino acids and pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1980-02-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174460-A1 | AFMT ANALOGS AND THEIR USE IN METHODS OF TREATING PARKINSON'S DISEASE | PARK7, SNCA, RHOT2 | BLM 1837/4885ODC1 2130/4885SLC7A5 772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.