Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 2/20 | 0.44 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078092 | 0.90 | GRIN1 (0.47) | GABBR2GABBR1TAAR1HTR2AGRIN1 | |
| SCHEMBL11083706 | 0.85 | GABBR2 (0.47) | GABBR2GABBR1TAAR1HTR2AAOC3 | |
| SCHEMBL12638434 | 0.82 | GRIN1 (0.50) | GABBR2GABBR1TAAR1HTR2AGRIN1 | |
| SCHEMBL4403167 | 0.79 | GRIN1 (0.64) | HTR2AGRIN1GRIN2A | |
| SCHEMBL18539220 | 0.78 | GBA1 (0.46) | GRIN1GRIN2AAOC3ANPEPERAP2 | |
| SCHEMBL17091537 | 0.78 | GBA1 (0.46) | GRIN1GRIN2AAOC3ANPEPERAP2 | |
| SCHEMBL11079597 | 0.77 | TAAR1 (0.53) | GABBR2GABBR1TAAR1HTR2AAOC3 | |
| SCHEMBL23081526 | 0.76 | TAAR1 (0.57) | TAAR1GRIN1GRIN2AAOC3 | |
| Hydrochloric Acid SCHEMBL11079216 | 0.76 | TAAR1 (0.57) | GABBR2GABBR1TAAR1HTR2AAOC3 | |
| SCHEMBL13911257 | 0.76 | TAAR1 (0.57) | TAAR1GRIN1GRIN2AAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |