Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.42 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078786 | 0.90 | GABBR2 (0.44) | GRIN1GRIN2AHTR2AGABBR2GABBR1 | |
| SCHEMBL12638434 | 0.86 | GRIN1 (0.50) | GRIN1GRIN2AALDH1A1HTR2AGABBR2 | |
| SCHEMBL11083706 | 0.82 | GABBR2 (0.47) | HTR2AGABBR2GABBR1TAAR1KDM4E | |
| SCHEMBL20663756 | 0.82 | GRIN1 (0.46) | GRIN1GRIN2AALDH1A1POLBMAPT | |
| SCHEMBL18539396 | 0.79 | GRIN1 (0.50) | GRIN1GRIN2AALDH1A1POLBMAPT | |
| SCHEMBL17091541 | 0.79 | GRIN1 (0.50) | GRIN1GRIN2AALDH1A1POLBMAPT | |
| SCHEMBL7791795 | 0.77 | TAAR1 (0.53) | GRIN1GRIN2AALDH1A1POLBMAPT | |
| SCHEMBL9973173 | 0.77 | GRIN1 (0.72) | GRIN1GRIN2AALDH1A1HTR2APOLB | |
| SCHEMBL4948330 | 0.77 | HTR2A (0.49) | ALDH1A1HTR2APOLBGABBR2GABBR1 | |
| SCHEMBL18539395 | 0.77 | GRIN1 (0.47) | GRIN1GRIN2AALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738647-B2 | Methods for the synthesis of polycyclic guanidine compounds | SAUDI ARAMCO TECHNOLOGIES COMPANY (SA) | 2017-08-22 | — | — | US | disclosed |
| US-20140194622-A1 | METHODS FOR THE SYNTHESIS OF POLYCYCLIC GUANIDINE COMPOUNDS | NOVOMER, INC. (US) | 2014-07-10 | — | — | US | disclosed |
| US-8642771-B2 | Methods for the synthesis of polycyclic guanidine compounds | NOVOMER, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-20120259112-A1 | METHODS FOR THE SYNTHESIS OF POLYCYCLIC GUANIDINE COMPOUNDS | NOVOMER, INC. (US) | 2012-10-11 | — | — | US | disclosed |
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194622-A1 | METHODS FOR THE SYNTHESIS OF POLYCYCLIC GUANIDINE COMPOUNDS | GNMT, GMPS, GDA | GRIN1 328/4885GRIN2A 192/4885ALDH1A1 2770/4885 |
| US-20120259112-A1 | METHODS FOR THE SYNTHESIS OF POLYCYCLIC GUANIDINE COMPOUNDS | GNMT, GMPS, GDA | GRIN1 328/4885GRIN2A 192/4885ALDH1A1 2770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.