Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26113493 | 0.77 | HDAC1 (0.65) | HDAC1HDAC6KDM4EPKMMEN1 | |
| SCHEMBL30597150 | 0.77 | HDAC1 (0.65) | HDAC1HDAC6KDM4EPKMMEN1 | |
| SCHEMBL29997473 | 0.74 | ALDH1A1 (0.39) | HDAC1HDAC6KDM4EPKMNFKB1 | |
| SCHEMBL11079589 | 0.73 | MAPK1 (0.44) | HDAC1HDAC6KDM4EPKMNFKB1 | |
| SCHEMBL26587823 | 0.70 | HDAC1 (0.48) | HDAC1HDAC6MEN1KMT2AALDH1A1 | |
| SCHEMBL26109947 | 0.68 | HDAC1 (0.48) | HDAC1HDAC6KDM4EMEN1KMT2A | |
| SCHEMBL31357125 | 0.68 | HDAC1 (0.48) | HDAC1HDAC6KDM4EMEN1KMT2A | |
| SCHEMBL11077466 | 0.68 | PLA2G10 (0.52) | KDM4EPKMGPR119PLA2G10PLA2G5 | |
| SCHEMBL17153096 | 0.68 | NR1H2 (0.45) | HDAC1HDAC6KMT2AALDH1A1LMNA | |
| SCHEMBL10913751 | 0.68 | KMT2A (0.54) | HDAC1HDAC6KDM4ECASP3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4483988-A | Substituted derivatives of 4-t-alkoxycarbonyl-piperazin-2-ones | RICHARDSON MERRELL INC. (US) | 1984-11-20 | — | — | US | disclosed |
| US-4435571-A | 5-(Substituted benzyl)-6-oxo-2-piperazine carboxylic acids and esters | RICHARDSON MERRELL INC. (US) | 1984-03-06 | — | — | US | disclosed |
| US-4341698-A | Enkaphalin derivatives | RICHARDSON-MERRELL INC. (US) | 1982-07-27 | — | — | US | disclosed |