Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MB | P02144 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL962066 | 0.87 | — | — | |
| SCHEMBL31149076 | 0.85 | — | — | |
| SCHEMBL5112385 | 0.74 | MB (0.33) | MBPARP1MMP12 | |
| Propionic Acid SCHEMBL21981161 | 0.74 | PARP1 (0.40) | MBPARP1MMP12MAPTALDH1A1 | |
| Thiazolidinedione SCHEMBL6598441 | 0.70 | GSK3A (0.64) | PARP1MAPTALDH1A1 | |
| Succinimide SCHEMBL30302994 | 0.66 | CRBN (0.69) | — | |
| Succinimide SCHEMBL8613393 | 0.64 | CRBN (0.65) | — | |
| SCHEMBL23008876 | 0.62 | — | — | |
| SCHEMBL10717060 | 0.62 | — | — | |
| SCHEMBL17982494 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0036762-B1 | A PHARMACEUTICAL FORMULATION OF A VINCA DIMER | ELI LILLY AND COMPANY (US) | 1984-10-10 | — | — | EP | disclosed |
| US-4357334-A | VINCA ALKALOIDS | ELI LILLY AND COMPANY (US) | 1982-11-02 | — | — | US | disclosed |
| EP-0036762-A2 | A pharmaceutical formulation of a vinca dimer | ELI LILLY AND COMPANY (US) | 1981-09-30 | — | — | EP | disclosed |