Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11074709 | 0.93 | CNR1 (0.56) | CNR1CNR2HIF1ATHRBADORA1 | |
| SCHEMBL11081687 | 0.90 | CNR1 (0.59) | CNR1CNR2PDE10ATHRBADORA1 | |
| SCHEMBL10973972 | 0.90 | CNR1 (0.57) | CNR1CNR2THRBADORA1PDE1A | |
| SCHEMBL11071848 | 0.89 | CNR1 (0.57) | CNR1CNR2THRBADORA1PDE1A | |
| SCHEMBL11070514 | 0.88 | CNR1 (0.57) | CNR1CNR2THRBADORA1PDE1A | |
| SCHEMBL10972776 | 0.85 | CNR1 (0.54) | CNR1CNR2THRBADORA1PDE1A | |
| SCHEMBL11074341 | 0.84 | CNR1 (0.54) | CNR1CNR2THRBADORA1PDE1A | |
| SCHEMBL11081203 | 0.83 | CNR1 (0.51) | CNR1CNR2THRBLMNAALDH1A1 | |
| SCHEMBL11340568 | 0.83 | CNR1 (0.52) | CNR1CNR2PDE10ATHRBADORA1 | |
| SCHEMBL844571 | 0.83 | CNR1 (0.79) | CNR1CNR2THRBADORA1PDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451467-A | HYPOTENSIVE AGENTS | Ishikawa, Masayuki (JP) | 1984-05-29 | — | — | US | disclosed |
| EP-0056637-A1 | 4(3H)-quinazolinone derivatives, process for production thereof and pharmaceutical compositions comprising said compounds | Ishikawa, Masayuki (JP) | 1982-07-28 | — | — | EP | disclosed |