Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.39 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11082671 | 0.81 | MAOA (0.45) | MAOAMAOBMAP1LC3BMAP1LC3ALNPEP | |
| SCHEMBL11087329 | 0.80 | MAOA (0.37) | MAOAMAOBMAP1LC3BMAP1LC3ALNPEP | |
| SCHEMBL11071975 | 0.76 | AR (0.45) | MAOAMAOBMAP1LC3BMAP1LC3ALNPEP | |
| SCHEMBL11076375 | 0.75 | MAOA (0.40) | MAOAMAOBMAP1LC3BMAP1LC3ALNPEP | |
| SCHEMBL1710869 | 0.74 | MAOA (0.41) | MAOAMAOBLNPEPALDH1A1LMNA | |
| SCHEMBL3390734 | 0.74 | MAOA (0.41) | MAOAMAOBLNPEPALDH1A1LMNA | |
| SCHEMBL13459732 | 0.72 | MAOA (0.46) | MAOAMAOBMAP1LC3BMAP1LC3ALNPEP | |
| SCHEMBL11083428 | 0.72 | KMT2A (0.52) | ALDH1A1L3MBTL1LMNACYSLTR2CYSLTR1 | |
| SCHEMBL11076101 | 0.72 | CYSLTR2 (0.51) | MAOBALDH1A1CYSLTR2CYSLTR1PTGS2 | |
| SCHEMBL11077922 | 0.72 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |