Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A2 | O15244 | 7/20 | 0.91 |
| ▸ | SLC22A1 | O15245 | 7/20 | 0.91 |
| ▸ | SLC22A3 | O75751 | 7/20 | 0.91 |
| ▸ | PLAU | P00749 | 7/20 | 0.91 |
| ▸ | NOS3 | P29474 | 2/20 | 0.71 |
| ▸ | NOS1 | P29475 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.60 |
| ▸ | HTR3B | O95264 | 5/20 | 0.60 |
| ▸ | HTR3A | P46098 | 5/20 | 0.60 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.60 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.60 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811970 | 0.95 | SLC22A2 (1.00) | SLC22A2SLC22A1SLC22A3PLAUNOS3 | |
| Hydrochloric Acid SCHEMBL9957964 | 0.93 | SLC22A2 (0.95) | SLC22A2SLC22A1SLC22A3PLAUNOS3 | |
| Bicarbonate SCHEMBL27495064 | 0.86 | SLC22A2 (0.83) | SLC22A2SLC22A1SLC22A3PLAUNOS3 | |
| Nitric Acid SCHEMBL4613845 | 0.81 | PLAU (0.73) | SLC22A2SLC22A1SLC22A3PLAUNOS3 | |
| SCHEMBL19038540 | 0.77 | SLC22A2 (0.68) | SLC22A2SLC22A1SLC22A3PLAUNOS3 | |
| SCHEMBL319881 | 0.76 | NOS1 (0.66) | SLC22A2SLC22A1SLC22A3PLAUNOS3 | |
| SCHEMBL12347777 | 0.76 | NOS1 (0.63) | SLC22A2SLC22A1SLC22A3PLAUNOS3 | |
| Hydrochloric Acid SCHEMBL27942258 | 0.76 | SLC22A2 (0.65) | SLC22A2SLC22A1SLC22A3PLAUNOS3 | |
| SCHEMBL15561449 | 0.75 | NOS1 (0.70) | SLC22A2SLC22A1SLC22A3PLAUNOS3 | |
| SCHEMBL166140 | 0.75 | SLC22A2 (1.00) | SLC22A2SLC22A1SLC22A3PLAUPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |