Tenivastatin

Tenivastatin

SCHEMBL110804

CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)[C@H]21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLCO1B1 Q9Y6L6 4/20 1.00
HMGCR P04035 11/20 0.84
HDAC1 Q13547 3/20 0.83
HDAC2 Q92769 3/20 0.83
HDAC6 Q9UBN7 3/20 0.83
SLC22A8 Q8TCC7 1/20 0.64
SLCO1B3 Q9NPD5 1/20 0.64
CYP3A4 P08684 3/20 0.61
USP2 O75604 2/20 0.61
ALDH1A1 P00352 2/20 0.61
TSHR P16473 2/20 0.61
ALOX15 P16050 2/20 0.61
KDM4E B2RXH2 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.61
NR1I2 O75469 1/20 0.61
ABCB11 O95342 1/20 0.61
NR3C1 P04150 1/20 0.61
PGR P06401 1/20 0.61
ABCB1 P08183 1/20 0.61
ADORA3 P0DMS8 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tenivastatin SCHEMBL28594403 1.00 SLCO1B1 (1.00) SLCO1B1HMGCRHDAC1HDAC2HDAC6
Tenivastatin SCHEMBL28594405 1.00 SLCO1B1 (1.00) SLCO1B1HMGCRHDAC1HDAC2HDAC6
Tenivastatin SCHEMBL14137685 1.00 SLCO1B1 (1.00) SLCO1B1HMGCRHDAC1HDAC2HDAC6
Tenivastatin SCHEMBL3694911 1.00 SLCO1B1 (1.00) SLCO1B1HMGCRHDAC1HDAC2HDAC6
Tenivastatin SCHEMBL14420544 1.00 SLCO1B1 (1.00) SLCO1B1HMGCRHDAC1HDAC2HDAC6
Tenivastatin SCHEMBL13934502 1.00 SLCO1B1 (1.00) SLCO1B1HMGCRHDAC1HDAC2HDAC6
Tenivastatin SCHEMBL25366987 1.00 SLCO1B1 (1.00) SLCO1B1HMGCRHDAC1HDAC2HDAC6
Tenivastatin SCHEMBL8239454 1.00 SLCO1B1 (1.00) SLCO1B1HMGCRHDAC1HDAC2HDAC6
Tenivastatin SCHEMBL28618339 0.99 SLCO1B1 (0.98) SLCO1B1HMGCRHDAC1HDAC2HDAC6
Tenivastatin SCHEMBL2987588 0.99 SLCO1B1 (0.98) SLCO1B1HMGCRHDAC1HDAC2HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 210 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116744934-A Inhaled statins for the treatment of viral respiratory diseases 加利福尼亚大学董事会 2023-09-12 CN claimed
US-20230172849-A1 INHALED STATINS FOR TREATMENT OF VIRAL RESPIRATORY DISEASES UNIV CALIFORNIA (US) 2023-06-08 US claimed
EP-4146340-A1 INHALED STATINS FOR TREATMENT OF VIRAL RESPIRATORY DISEASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-03-15 EP claimed
US-20230014352-A1 INHALED STATINS AS BRONCHODILATORS TO IMPROVE LUNG FUNCTION IN RESPIRATORY DISEASES BETH ISRAEL DEACONESS MEDICAL CENTER, INC. 2023-01-19 US claimed
EP-3946268-A1 INHALED STATINS AS BRONCHODILATORS TO IMPROVE LUNG FUNCTION IN RESPIRATORY DISEASES The Regents of The University of California (US) 2022-02-09 EP claimed
WO-2021226479-A1 INHALED STATINS FOR TREATMENT OF VIRAL RESPIRATORY DISEASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-11-11 WO claimed
EP-2923698-B1 STATIN COMPOUND FOR USE IN TREATING OBESITY, HYPERTENSION AND HYPERLIPAEMIA BY INTRAOSSEOUS ADMINISTRATION UNIV PEKING THIRD HOSPITAL (CN) 2021-04-28 EP claimed
WO-2020205663-A1 INHALED STATINS AS BRONCHODILATORS TO IMPROVE LUNG FUNCTION IN RESPIRATORY DISEASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-10-08 WO claimed
EP-3290022-B1 USE OF STATINS IN THE TREATMENT OF ISCHEMIC DISEASES UNIV PEKING THIRD HOSPITAL (CN) 2020-04-01 EP claimed
US-10179121-B2 Use of statins in the treatment of ischemic diseases PEKING UNIVERSITY THIRD HOSPITAL (CN) 2019-01-15 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
EP-1951224-A2 METHODS FOR TREATING DISORDERS ASSOCIATED WITH HYPERLIPIDEMIA IN A MAMMAL Aegerion Pharmaceuticals (US) 2008-08-06 EP claimed
EP-1945205-A2 METHODS AND COMPOSITIONS FOR TREATING DISORDERS ASSOCIATED WITH HYPERLIPIDEMIA IN A MAMMAL Aegerion Pharmaceuticals (US) 2008-07-23 EP claimed
WO-2007120144-A1 BIOACTIVE-RICH CONCENTRATES AND NUTRITIVE AND THERAPEUTIC PRODUCTS CONTAINING SAME NATURI LLC (US) 2007-10-25 WO claimed
US-20070243233-A1 Bioactive-rich concentrates and nutritive and therapeutic products containing same NATURI LLC (US) 2007-10-18 US claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
WO-2007047880-A2 COMPOSITIONS FOR LOWERING SERUM CHOLESTEROL AND/OR TRIGLYCERIDES AEGERION PHARMACEUTICALS (US) 2007-04-26 WO claimed
US-20070093527-A1 Methods for treating disorders associated with hyperlipidemia in a mammal AEGERION PHARMACEUTICALS, INC. 2007-04-26 US claimed
WO-2007047725-A2 METHODS FOR TREATING DISORDERS ASSOCIATED WITH HYPERLIPIDEMIA IN A MAMMAL AEGERION PHARMACEUTICALS (US) 2007-04-26 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070093527-A1 Methods for treating disorders associated with hyperlipidemia in a mammal HMGCR, MTTP, CETP SLCO1B1 563/4885HMGCR 1/4885HDAC1 2015/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.