Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 0.98 |
| ▸ | HMGCR | P04035 | 11/20 | 0.83 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.81 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.81 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.81 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.63 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.60 |
| ▸ | PGR | P06401 | 1/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tenivastatin SCHEMBL28618339 | 1.00 | SLCO1B1 (0.98) | SLCO1B1HMGCRHDAC1HDAC2HDAC6 | |
| Tenivastatin SCHEMBL3694911 | 0.99 | SLCO1B1 (1.00) | SLCO1B1HMGCRHDAC1HDAC2HDAC6 | |
| Tenivastatin SCHEMBL28594405 | 0.99 | SLCO1B1 (1.00) | SLCO1B1HMGCRHDAC1HDAC2HDAC6 | |
| Tenivastatin SCHEMBL8239454 | 0.99 | SLCO1B1 (1.00) | SLCO1B1HMGCRHDAC1HDAC2HDAC6 | |
| Tenivastatin SCHEMBL13934502 | 0.99 | SLCO1B1 (1.00) | SLCO1B1HMGCRHDAC1HDAC2HDAC6 | |
| Tenivastatin SCHEMBL25366987 | 0.99 | SLCO1B1 (1.00) | SLCO1B1HMGCRHDAC1HDAC2HDAC6 | |
| Tenivastatin SCHEMBL110804 | 0.99 | SLCO1B1 (1.00) | SLCO1B1HMGCRHDAC1HDAC2HDAC6 | |
| Tenivastatin SCHEMBL14420544 | 0.99 | SLCO1B1 (1.00) | SLCO1B1HMGCRHDAC1HDAC2HDAC6 | |
| Tenivastatin SCHEMBL28594403 | 0.99 | SLCO1B1 (1.00) | SLCO1B1HMGCRHDAC1HDAC2HDAC6 | |
| Tenivastatin SCHEMBL14137685 | 0.99 | SLCO1B1 (1.00) | SLCO1B1HMGCRHDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118702661-A | Separation and purification method of simvastatin | 江苏阿尔法药业股份有限公司 | 2024-09-27 | — | — | CN | claimed |
| CN-117903175-A | Synthesis method and application of lithium pyrrolidine | 浙江江北药业有限公司 | 2024-04-19 | — | — | CN | claimed |
| CN-114478617-A | Preparation method of intermediate of simvastatin ammonium salt | 上虞京新药业有限公司 | 2022-05-13 | — | — | CN | claimed |
| US-12371723-B2 | Variant LovD polypeptides and their uses | CODEXIS, INC. (US) | 2025-07-29 | — | — | US | disclosed |
| US-20240368649-A1 | LOV-D ACYLTRANSFERASE MEDIATED ACYLATION | CODEXIS INC (US) | 2024-11-07 | — | — | US | disclosed |
| CN-118702661-A | Separation and purification method of simvastatin | 江苏阿尔法药业股份有限公司 | 2024-09-27 | — | — | CN | disclosed |
| CN-118702661-A | Separation and purification method of simvastatin | 江苏阿尔法药业股份有限公司 | 2024-09-27 | — | — | CN | disclosed |
| CN-118620863-A | Acyltransferase mutant and application thereof | 苏州诺恩斯生物科技有限公司 | 2024-09-10 | — | — | CN | disclosed |
| US-12060592-B2 | Lov-D acyltransferase mediated acylation | CODEXIS, INC. (US) | 2024-08-13 | — | — | US | disclosed |
| US-20240218407-A1 | VARIANT LOVD POLYPEPTIDES AND THEIR USES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2024-07-04 | — | — | US | disclosed |
| CN-114478617-B | Preparation method of simvastatin intermediate | 绍兴京新药业有限公司 | 2024-06-21 | — | — | CN | disclosed |
| US-6797831-B2 | Process for lactonization to produce simvastatin | AUROBINDO PHARMA LIMITED (IN) | 2004-09-28 | — | — | US | disclosed |
| US-20040077884-A1 | Process for lactonization to produce highly pure simvastatin | AUROBINDO PHARMA LIMITED (IN) | 2004-04-22 | — | — | US | disclosed |
| US-20040019225-A1 | Process for lactonization to produce simvastatin | AUROBINDO PHARMA LIMITED (IN) | 2004-01-29 | — | — | US | disclosed |
| US-6649775-B2 | Lactonization of acid derivative to ester in the presence of a dehydrating agent without acid catalyst under nitrogen sweep, crystallizing the lactone in presence of a solvent | CHEIL JEDANG CORPORATION (KR) | 2003-11-18 | — | — | US | disclosed |
| US-20030109723-A1 | Processing method of lactionization in the preparation of statins | CJ CORP. (KR) | 2003-06-12 | — | — | US | disclosed |
| EP-1316552-A1 | Processing method of lactonization in the preparation of statins | CJ Corporation (KR) | 2003-06-04 | — | — | EP | disclosed |
| US-20030050482-A1 | Process of lactonization in the preparation of statins | CJ HEALTHCARE CORPORATION (KR) | 2003-03-13 | — | — | US | disclosed |
| EP-1288212-A1 | Process of lactonization in the preparation of statins | CHEIL JEDANG Corporation (KR) | 2003-03-05 | — | — | EP | disclosed |
| US-4916239-A | Process for the lactonization of mevinic acids and analogs thereof | MERCK & CO., INC. (US) | 1990-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030109723-A1 | Processing method of lactionization in the preparation of statins | HMGCR, COASY, LSS | SLCO1B1 319/4885HMGCR 1/4885HDAC1 3787/4885 |
| US-20240368649-A1 | LOV-D ACYLTRANSFERASE MEDIATED ACYLATION | ACAT2, LCAT, ACOT7 | SLCO1B1 983/4885HMGCR 7/4885HDAC1 318/4885 |
| US-12060592-B2 | Lov-D acyltransferase mediated acylation | ACAT2, LCAT, ACOT7 | SLCO1B1 983/4885HMGCR 7/4885HDAC1 318/4885 |
| US-20240218407-A1 | VARIANT LOVD POLYPEPTIDES AND THEIR USES | LCAT, HMGCR, FNTA | SLCO1B1 615/4885HMGCR 2/4885HDAC1 4177/4885 |
| US-20040077884-A1 | Process for lactonization to produce highly pure simvastatin | HMGCR, LIPA, APOB | SLCO1B1 892/4885HMGCR 1/4885HDAC1 183/4885 |
| US-12371723-B2 | Variant LovD polypeptides and their uses | LCAT, HMGCR, FNTA | SLCO1B1 615/4885HMGCR 2/4885HDAC1 4177/4885 |
| US-20040019225-A1 | Process for lactonization to produce simvastatin | SMYD2, SMYD3, LIPA | SLCO1B1 937/4885HMGCR 6/4885HDAC1 134/4885 |
| US-20030050482-A1 | Process of lactonization in the preparation of statins | COASY, HMGCR, LSS | SLCO1B1 522/4885HMGCR 2/4885HDAC1 3377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.