Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 7/20 | 0.35 |
| ▸ | CD44 | P16070 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31130652 | 0.85 | GAA (0.58) | GAAHTR2CPNMTCD44MAOB | |
| SCHEMBL27901543 | 0.82 | GAA (0.53) | GAAPDE4BPDE3A | |
| Hydrochloric Acid SCHEMBL31233767 | 0.81 | GAA (0.52) | GAAPDE4BPDE3A | |
| SCHEMBL20092675 | 0.75 | GAA (0.89) | GAAPDE4BPDE3A | |
| SCHEMBL3617104 | 0.69 | GAA (0.56) | GAAPDE4BPDE3A | |
| SCHEMBL1875764 | 0.68 | — | — | |
| Hydrochloric Acid SCHEMBL30144072 | 0.67 | PNMT (0.39) | CYP3A4HTR2CPNMTCD44MAOB | |
| Hydrochloric Acid SCHEMBL31284488 | 0.67 | PNMT (0.39) | CYP3A4HTR2CPNMTCD44MAOB | |
| SCHEMBL31126172 | 0.67 | HTR2C (0.79) | CYP3A4HTR2CASIC3 | |
| SCHEMBL14719247 | 0.66 | PARP1 (0.48) | PNMTCD44MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478837-A | HYPOTENSIVE AGENTS | SANDOZ LTD. (CH) | 1984-10-23 | — | — | US | disclosed |
| US-3954754-A | ANTIHYPERTENSIVES | SANDOZ LTD. (CH) | 1976-05-04 | — | — | US | disclosed |