Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.48 |
| ▸ | CD44 | P16070 | 2/20 | 0.40 |
| ▸ | PNMT | P11086 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21372079 | 0.76 | PARP1 (0.41) | PARP1TNKSTNKS2PARP2ATM | |
| SCHEMBL29919865 | 0.76 | PARP1 (0.41) | PARP1TNKSTNKS2PARP2ATM | |
| SCHEMBL14718248 | 0.73 | PARP1 (0.39) | PARP1TNKSTNKS2PARP2ATM | |
| SCHEMBL14718856 | 0.71 | PARP1 (0.40) | PARP1TNKSTNKS2PARP2 | |
| SCHEMBL15084454 | 0.68 | PARP1 (0.40) | PARP1TNKSTNKS2PARP2ATM | |
| Hydrochloric Acid SCHEMBL17704119 | 0.67 | PARP1 (0.40) | PARP1TNKSTNKS2PARP2ATM | |
| SCHEMBL24000798 | 0.67 | ALDH1A1 (0.53) | ROCK2ATMNPSR1POLB | |
| SCHEMBL14718951 | 0.67 | PARP1 (0.38) | PARP1TNKSTNKS2PARP2ATM | |
| SCHEMBL11080801 | 0.66 | GAA (0.58) | CD44PNMTMAOB | |
| Hydrochloric Acid SCHEMBL30088846 | 0.66 | ALDH1A1 (0.52) | ROCK2ATMNPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053365-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | BIOMARIN PHARMACEUTICAL, INC. (US) | 2013-02-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053365-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | PARP1, PARP2, PARP3 | PARP1 1/4885CD44 4633/4885PNMT 1833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.