Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080805 | 0.75 | KMT2A (0.45) | NPC1TP53RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1295475 | 0.74 | ALOX5 (0.47) | NPC1TP53RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8145953 | 0.74 | ALDH1A1 (0.44) | NPC1TP53RAB9ASMN1; SMN2MAPT | |
| SCHEMBL24611526 | 0.73 | MAPT (0.56) | NPC1TP53RAB9ASMN1; SMN2MAPT | |
| SCHEMBL12736291 | 0.72 | NPC1 (0.39) | NPC1TP53RAB9ASMN1; SMN2MAPT | |
| SCHEMBL13225707 | 0.72 | NPC1 (0.42) | NPC1TP53RAB9ASMN1; SMN2MAPT | |
| SCHEMBL9925396 | 0.72 | KMT2A (0.41) | NPC1TP53RAB9ASMN1; SMN2MAPT | |
| SCHEMBL9925412 | 0.72 | ALDH1A1 (0.46) | NPC1TP53RAB9ASMN1; SMN2MAPT | |
| SCHEMBL20561794 | 0.72 | KMT2A (0.41) | NPC1TP53RAB9ASMN1; SMN2MAPT | |
| SCHEMBL27347187 | 0.72 | ALDH1A1 (0.42) | NPC1TP53RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002846-B1 | 3-THIENYLMALONIC ACIDS, THE CORRESPONDING DIESTERS AND THEIR PREPARATION | Océ-Andeno B.V. (NL) | 1984-05-23 | — | — | EP | disclosed |