Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8182080 | 0.83 | ENPP2 (0.48) | ENPP2AKR1C3AKR1C2ALDH1A1GRM4 | |
| SCHEMBL311851 | 0.83 | ENPP2 (0.48) | ENPP2AKR1C3AKR1C2ALDH1A1GRM4 | |
| SCHEMBL14211437 | 0.83 | ENPP2 (0.48) | ENPP2AKR1C3AKR1C2ALDH1A1GRM4 | |
| Hydrochloric Acid SCHEMBL14120652 | 0.81 | ENPP2 (0.46) | ENPP2AKR1C3AKR1C2ALDH1A1GRM4 | |
| Hydrochloric Acid SCHEMBL14121049 | 0.81 | ENPP2 (0.46) | ENPP2AKR1C3AKR1C2ALDH1A1GRM4 | |
| Hydrochloric Acid SCHEMBL14157349 | 0.81 | ENPP2 (0.46) | ENPP2AKR1C3AKR1C2ALDH1A1GRM4 | |
| SCHEMBL8954423 | 0.80 | LMNA (0.53) | ENPP2AKR1C3AKR1C2ALDH1A1GRM4 | |
| SCHEMBL13868984 | 0.80 | LMNA (0.53) | ENPP2AKR1C3AKR1C2ALDH1A1GRM4 | |
| SCHEMBL18185778 | 0.80 | LMNA (0.53) | ENPP2AKR1C3AKR1C2ALDH1A1GRM4 | |
| SCHEMBL7866855 | 0.78 | ENPP2 (0.52) | ENPP2AKR1C3AKR1C2ALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |