Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.43 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10993264 | 0.94 | PTGS2 (0.49) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL11175120 | 0.93 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| SCHEMBL7084889 | 0.85 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| SCHEMBL7084428 | 0.85 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| SCHEMBL11083056 | 0.84 | NPC1 (0.40) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL7084894 | 0.77 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| SCHEMBL11095461 | 0.77 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| SCHEMBL6585407 | 0.76 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6583564 | 0.76 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL10887823 | 0.74 | LMNA (0.41) | MAPK14MAPK13MAPK12MAPK11PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4472422-A | Antihypertensive 4,5-diaryl-α-polyfluoro-alkyl-1H-imidazole-2-methanamines | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-09-18 | — | — | US | disclosed |