Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 12/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PSIP1 | O75475 | 2/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11075393 | 0.80 | BRD4 (0.37) | BRD4SRD5A1 | |
| SCHEMBL11087497 | 0.78 | BRD4 (0.38) | BRD4SRD5A1 | |
| SCHEMBL11090881 | 0.77 | SRD5A1 (0.53) | BRD4SRD5A1 | |
| SCHEMBL11080957 | 0.77 | BRD4 (0.37) | BRD4SRD5A1 | |
| SCHEMBL11111651 | 0.77 | BRD4 (0.55) | BRD4SRD5A1 | |
| SCHEMBL11076487 | 0.77 | BRD4 (0.37) | BRD4SRD5A1 | |
| SCHEMBL11080446 | 0.77 | TSHR (0.41) | GAA | |
| SCHEMBL11078183 | 0.77 | BRD4 (0.35) | BRD4SRD5A1 | |
| SCHEMBL11072826 | 0.76 | BRD4 (0.53) | BRD4SRD5A1 | |
| SCHEMBL11286306 | 0.75 | BRD4 (0.39) | BRD4GAAPSIP1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |