Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NME2 | P22392 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11087999 | 0.94 | MEN1 (0.58) | NME2POLBMEN1KMT2AHPGD | |
| SCHEMBL11086228 | 0.93 | NME2 (0.56) | NME2POLBKMT2AHPGDNPSR1 | |
| SCHEMBL10851546 | 0.90 | NME2 (0.65) | NME2POLBMEN1KMT2AHPGD | |
| SCHEMBL10851536 | 0.90 | NME2 (0.65) | NME2POLBMEN1KMT2AHPGD | |
| SCHEMBL11083677 | 0.87 | ALOX5 (0.55) | NME2MEN1KMT2AALOX5 | |
| SCHEMBL10851910 | 0.84 | MEN1 (0.58) | NME2MEN1KMT2AALOX5 | |
| SCHEMBL10851904 | 0.84 | MEN1 (0.58) | NME2MEN1KMT2AALOX5 | |
| SCHEMBL10851419 | 0.84 | MEN1 (0.54) | NME2POLBMEN1KMT2AHPGD | |
| SCHEMBL10851428 | 0.84 | MEN1 (0.54) | NME2POLBMEN1KMT2AHPGD | |
| SCHEMBL10851437 | 0.84 | MEN1 (0.54) | NME2POLBMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4428952-A | Substituted pyrrolo[2,1-b]quinazolines and pyrido[2,1-b]quinazolines useful for the treatment of or the prevention of gastrointestinal ulcers | FARMITALIA CARLO ERBA S.P.A. (IT) | 1984-01-31 | — | — | US | disclosed |