Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5904146 | 0.82 | PDE10A (0.60) | MAP2K1LMNAPDE3BPDE3AKDM4E | |
| SCHEMBL11199895 | 0.78 | MAP2K1 (0.49) | MAP2K1LMNAPDE3BPDE3AKDM4E | |
| SCHEMBL10890724 | 0.78 | PDE3B (0.42) | PDE3BPDE3ATDP1ALDH1A1BRD4 | |
| SCHEMBL25904292 | 0.78 | PDE3B (0.57) | MAP2K1LMNAPDE3BPDE3AKDM4E | |
| SCHEMBL11010732 | 0.77 | PDE4A (0.53) | PDE3BPDE3AKDM4EMAPTALDH1A1 | |
| SCHEMBL11110728 | 0.76 | GSK3B (0.46) | MAP2K1PDE3BPDE3AKDM4EMAPT | |
| SCHEMBL11007460 | 0.75 | PTGS2 (0.41) | PDE3BPDE3AKDM4EMAPTTDP1 | |
| SCHEMBL9382851 | 0.74 | ABL1 (0.47) | KDM4EMAPTALDH1A1SMN1; SMN2BACE1 | |
| SCHEMBL11117779 | 0.74 | PDE3B (0.56) | LMNAPDE3BPDE3AKDM4EMAPT | |
| SCHEMBL10997163 | 0.73 | PDE3B (0.67) | MAP2K1PDE3BPDE3AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109628-A1 | 2(1H)-pyridinones and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1984-05-30 | — | — | EP | disclosed |