Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5904146 | 0.78 | PDE10A (0.60) | MAP2K1PDE10ALMNAPDE3BPDE3A | |
| SCHEMBL11086702 | 0.78 | MAP2K1 (0.53) | MAP2K1PDE10ALMNAPDE3BPDE3A | |
| SCHEMBL10994404 | 0.76 | PARP1 (0.45) | PDE10APDE3BPDE3ATGFBR1KDM4E | |
| SCHEMBL10889141 | 0.73 | PDE3B (0.68) | PDE10ALMNAPDE3BPDE3AKDM4E | |
| SCHEMBL10999103 | 0.72 | SMN1; SMN2 (0.45) | PDE10AKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL25904292 | 0.71 | PDE3B (0.57) | MAP2K1LMNAPDE3BPDE3AKDM4E | |
| SCHEMBL22721784 | 0.70 | GSTP1 (0.70) | KDM4EMAPTTHRBPKMTDP1 | |
| SCHEMBL9705393 | 0.70 | NOTUM (0.45) | MAP2K1PDE10ATGFBR1KDM4EMAPT | |
| SCHEMBL25903697 | 0.70 | PDE3B (0.56) | MAP2K1LMNAPDE3BPDE3AKDM4E | |
| SCHEMBL17980649 | 0.69 | MAP2K1 (0.54) | MAP2K1PDE10ALMNAPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0074091-A2 | 2(1H)-pyridinones and preparation thereof | STERLING DRUG INC. (US) | 1983-03-16 | — | — | EP | disclosed |