Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 3/20 | 0.47 |
| ▸ | CASP7 | P55210 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.45 |
| ▸ | PTAFR | P25105 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11267569 | 0.89 | ALPG (0.47) | SMN1; SMN2NPC1RAB9AKDM4ECASP1 | |
| SCHEMBL28381549 | 0.88 | ALPG (0.48) | SMN1; SMN2KDM4EGAAMAPTHTT | |
| SCHEMBL28659590 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AKDM4ECASP1 | |
| SCHEMBL11009173 | 0.81 | ALPG (0.71) | SMN1; SMN2NPC1RAB9AKDM4ECASP1 | |
| SCHEMBL11089567 | 0.81 | PTAFR (0.43) | SMN1; SMN2KDM4ECASP1CASP7GAA | |
| SCHEMBL10339599 | 0.80 | ALDH1A1 (0.47) | SMN1; SMN2NPC1RAB9AKDM4ECASP1 | |
| SCHEMBL28883171 | 0.79 | KDM4E (0.61) | SMN1; SMN2NPC1RAB9AKDM4ECASP1 | |
| SCHEMBL11002512 | 0.79 | ALPG (0.58) | SMN1; SMN2NPC1RAB9AKDM4ECASP1 | |
| SCHEMBL11547459 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM4ECASP1CASP7GAA | |
| SCHEMBL11089935 | 0.78 | ALPG (0.46) | ALPGTBXAS1PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4457927-A | Pyrido[2,1-b]quinazolinone derivatives and the preparation and use thereof | SCHERING, AKTIENGESELLSCHAFT (DE) | 1984-07-03 | — | — | US | disclosed |
| EP-0011142-B1 | PYRIDO (2,1-B) QUINAZOLINONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-12-29 | — | — | EP | disclosed |
| EP-0011142-A1 | Pyrido (2,1-b) quinazolinones, their preparation and pharmaceutical compositions containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-05-28 | — | — | EP | disclosed |