SCHEMBL11547459

SCHEMBL11547459

Cc1ccc2nc3cc4c(=O)n5cc(C)ccc5nc4cc3c(=O)n2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.47
ALPG P10696 1/20 0.47
AKR1B1 P15121 1/20 0.47
ALDH1A1 P00352 9/20 0.45
KDM4E B2RXH2 8/20 0.44
GAA P10253 6/20 0.44
HPGD P15428 4/20 0.44
GLA P06280 4/20 0.44
CASP1 P29466 4/20 0.44
CASP7 P55210 4/20 0.44
HSD17B10 Q99714 4/20 0.44
PARP1 P09874 1/20 0.44
PKM P14618 1/20 0.44
MEN1 O00255 6/20 0.44
KMT2A Q03164 6/20 0.44
S1PR4 O95977 1/20 0.44
S1PR1 P21453 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
LMNA P02545 2/20 0.42
MAPT P10636 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28659590 0.90 SMN1; SMN2 (0.51) SMN1; SMN2ALPGAKR1B1ALDH1A1KDM4E
Hydrochloric Acid SCHEMBL10663030 0.88 ALPG (0.41) SMN1; SMN2ALPGAKR1B1ALDH1A1KDM4E
SCHEMBL11267569 0.85 ALPG (0.47) SMN1; SMN2ALPGAKR1B1ALDH1A1KDM4E
SCHEMBL28352180 0.83 ALDH1A1 (0.61) SMN1; SMN2ALDH1A1KDM4EGAAHPGD
SCHEMBL13923498 0.82 ALPG (0.71) SMN1; SMN2ALPGALDH1A1KDM4EGAA
SCHEMBL11269862 0.82 ALPG (0.64) SMN1; SMN2ALPGAKR1B1ALDH1A1KDM4E
SCHEMBL11087151 0.79 SMN1; SMN2 (0.47) SMN1; SMN2ALPGAKR1B1ALDH1A1KDM4E
SCHEMBL11083819 0.78 ALPG (0.47) ALPGALDH1A1KDM4EGAAHPGD
SCHEMBL28673639 0.78 ALPG (0.59) SMN1; SMN2ALPGAKR1B1ALDH1A1KDM4E
SCHEMBL11009173 0.76 ALPG (0.71) SMN1; SMN2ALPGAKR1B1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4132851-A Process for producing quinazolone derivatives TOYO SODA MANUFACTURING CO., LTD. (JP) 1979-01-02 US disclosed