Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11090808 | 0.89 | MAPT (0.66) | MAPTALDH1A1SMN1; SMN2KMT2ARAB9A | |
| SCHEMBL10925574 | 0.83 | MAPT (0.85) | MAPTALDH1A1SMN1; SMN2KMT2ARAB9A | |
| SCHEMBL5859510 | 0.81 | ALDH1A1 (0.62) | MAPTALDH1A1SMN1; SMN2KMT2ARAB9A | |
| SCHEMBL3809960 | 0.81 | ALDH1A1 (1.00) | MAPTALDH1A1SMN1; SMN2KMT2ARAB9A | |
| SCHEMBL653579 | 0.79 | ALDH1A1 (1.00) | MAPTALDH1A1SMN1; SMN2KMT2ARAB9A | |
| SCHEMBL14782691 | 0.79 | MAOA (0.66) | MAPTGAAL3MBTL1HSD17B10MAOA | |
| Hydrochloric Acid SCHEMBL5506486 | 0.78 | KCNH2 (0.45) | MAPTALDH1A1SMN1; SMN2KMT2ARAB9A | |
| Isoxepac SCHEMBL24970 | 0.78 | AKR1B1 (0.81) | MAPTALDH1A1RAB9AAKR1B1 | |
| Isoxepac SCHEMBL29588437 | 0.78 | AKR1B1 (0.81) | MAPTALDH1A1RAB9AAKR1B1 | |
| SCHEMBL10867494 | 0.78 | ALDH1A1 (0.76) | MAPTALDH1A1SMN1; SMN2KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448786-A | TREATMENT AND PREVENTION OF CALCIUM OXALATE KIDNEY STONES | MERCK & CO., INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4349561-A | 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase | MERCK & CO., INC. (US) | 1982-09-14 | — | — | US | disclosed |