Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10989413 | 0.87 | BRD4 (0.42) | BRD4HTR2AHTR2CPTGDR2BTK | |
| SCHEMBL11079151 | 0.86 | NPC1 (0.40) | BRD4HTR2AHTR2CPTGDR2TUBB4A | |
| SCHEMBL10989873 | 0.85 | BRD4 (0.43) | BRD4HTR2AHTR2CPTGDR2BTK | |
| SCHEMBL10832434 | 0.85 | GAA (0.47) | BRD4PTGDR2TUBB4ATUBBTUBA3C | |
| SCHEMBL11080541 | 0.84 | BRD4 (0.42) | BRD4HTR2AHTR2CPTGDR2BTK | |
| SCHEMBL10924753 | 0.84 | BRD4 (0.47) | BRD4BRD2CREBBP | |
| SCHEMBL10982627 | 0.82 | BRD4 (0.43) | BRD4HTR2AHTR2CPTGDR2BTK | |
| SCHEMBL10984221 | 0.75 | NPC1 (0.39) | BRD4HTR2AHTR2CBRD2CSF1R | |
| SCHEMBL10977438 | 0.75 | CSF1R (0.37) | BRD4HTR2AHTR2CPTGDR2BRD2 | |
| SCHEMBL10951500 | 0.74 | BRD4 (0.40) | BRD4HTR2AHTR2CPTGDR2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4467096-A | ANTIDIABETIC AGENTS, INTERMEDIATES THEREFOR | SANDOZ, INC. (US) | 1984-08-21 | — | — | US | disclosed |
| US-4421752-A | ANTIDIABETIC AGENT | SANDOZ, INC. (US) | 1983-12-20 | — | — | US | disclosed |
| US-4336391-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |