Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10984221 | 0.89 | NPC1 (0.39) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL10977643 | 0.87 | NPC1 (0.38) | NPC1RAB9A | |
| SCHEMBL11088526 | 0.86 | BRD4 (0.47) | HTR2AHTR2CBRD4TUBB4ATUBB | |
| SCHEMBL11086175 | 0.86 | GABRA1 (0.39) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL10831572 | 0.85 | KDM4E (0.42) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL10977892 | 0.83 | POLB (0.43) | NPC1RAB9APOLBKMT2A | |
| SCHEMBL10832434 | 0.81 | GAA (0.47) | BRD4KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL10981373 | 0.77 | MAPT (0.36) | NPC1RAB9ABRD4KMT2A | |
| SCHEMBL10831728 | 0.76 | BRD4 (0.34) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL10831731 | 0.76 | TLR8 (0.34) | NPC1RAB9AGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4467096-A | ANTIDIABETIC AGENTS, INTERMEDIATES THEREFOR | SANDOZ, INC. (US) | 1984-08-21 | — | — | US | disclosed |
| US-4421752-A | ANTIDIABETIC AGENT | SANDOZ, INC. (US) | 1983-12-20 | — | — | US | disclosed |
| US-4336391-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |