Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 11/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.46 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.39 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11094389 | 0.97 | MAOB (0.48) | MAOBHRH3FOXM1BCHEACHE | |
| Bromide SCHEMBL11097110 | 0.93 | CHRNB2 (0.43) | MAOBHRH3FOXM1ACHECHRNB2 | |
| Bromide SCHEMBL11088807 | 0.83 | FOXM1 (0.41) | MAOBFOXM1XDHCHRNB2CHRNB4 | |
| Bromide SCHEMBL11181029 | 0.81 | MAOB (0.43) | MAOBHRH3BCHEACHEXDH | |
| Bromide SCHEMBL11088735 | 0.81 | MAOB (0.42) | MAOBHRH3BCHEACHEXDH | |
| Bromide SCHEMBL11171168 | 0.81 | MAOB (0.42) | MAOBHRH3BCHEACHEXDH | |
| Bromide SCHEMBL11084644 | 0.80 | CHRNB2 (0.44) | MAOBXDHCHRNB2CHRNB4CHRNA3 | |
| Bromide SCHEMBL11167726 | 0.79 | KDM4E (0.39) | MAOBFOXM1ACHE | |
| Bromide SCHEMBL11090826 | 0.79 | CHRNB2 (0.43) | MAOBXDHCHRNB2CHRNB4CHRNA3 | |
| Bromide SCHEMBL11097385 | 0.78 | MAOB (0.41) | MAOBHRH3BCHEACHEXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0057362-B1 | DIBENZOFURANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | BASF Aktiengesellschaft (DE) | 1984-06-20 | — | — | EP | disclosed |
| US-4376776-A | Dibenzofuran derivatives and their use for controlling fungi | BASF AKTIENGESELLSCHAFT (DE) | 1983-03-15 | — | — | US | disclosed |
| EP-0057362-A1 | Dibenzofurane derivatives, process for their preparation and their use as fungicides | BASF Aktiengesellschaft (DE) | 1982-08-11 | — | — | EP | disclosed |