Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | FOXM1 | Q08050 | 4/20 | 0.37 |
| ▸ | MAOB | P27338 | 10/20 | 0.37 |
| ▸ | MAOA | P21397 | 6/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11094389 | 0.82 | MAOB (0.48) | FOXM1MAOBACHE | |
| Bromide SCHEMBL11089523 | 0.79 | MAOB (0.46) | FOXM1MAOBACHE | |
| Bromide SCHEMBL11167733 | 0.78 | MAOA (0.43) | KDM4EALDH1A1GAAHPGDMAOB | |
| Bromide SCHEMBL11088807 | 0.78 | FOXM1 (0.41) | KDM4EALDH1A1HPGDFOXM1MAOB | |
| Bromide SCHEMBL11097110 | 0.74 | CHRNB2 (0.43) | KDM4EALDH1A1GAAHPGDFOXM1 | |
| Bromide SCHEMBL11084644 | 0.71 | CHRNB2 (0.44) | KDM4EALDH1A1HPGDMAOBMAOA | |
| Bromide SCHEMBL11090826 | 0.70 | CHRNB2 (0.43) | KDM4EALDH1A1HPGDMAOBMAOA | |
| SCHEMBL11316127 | 0.69 | CHRNB2 (0.44) | KDM4EALDH1A1HPGDMAOBMAOA | |
| SCHEMBL10648746 | 0.64 | HSD17B3 (0.55) | KDM4EALDH1A1GAAHPGDMAOB | |
| Bromide SCHEMBL11088735 | 0.64 | MAOB (0.42) | KDM4EALDH1A1GAAHPGDMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4376776-A | Dibenzofuran derivatives and their use for controlling fungi | BASF AKTIENGESELLSCHAFT (DE) | 1983-03-15 | — | — | US | disclosed |
| EP-0057362-A1 | Dibenzofurane derivatives, process for their preparation and their use as fungicides | BASF Aktiengesellschaft (DE) | 1982-08-11 | — | — | EP | disclosed |