Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11879315 | 0.83 | ALDH1A1 (0.52) | ALDH1A1KMT2AGPR35SMN1; SMN2RAB9A | |
| SCHEMBL11095796 | 0.82 | ALDH1A1 (0.41) | ALDH1A1KMT2AGPR35SMN1; SMN2RAB9A | |
| SCHEMBL11808311 | 0.82 | ALDH1A1 (0.43) | ALDH1A1KMT2AGPR35SMN1; SMN2RAB9A | |
| SCHEMBL11092649 | 0.82 | TSHR (0.37) | ALDH1A1KMT2ARAB9ACYP3A4MEN1 | |
| SCHEMBL11579736 | 0.82 | MAPT (0.53) | ALDH1A1KMT2ASMN1; SMN2RAB9ACYP3A4 | |
| SCHEMBL11091737 | 0.81 | ALDH1A1 (0.40) | ALDH1A1KMT2ARAB9AMAPTMEN1 | |
| SCHEMBL11813021 | 0.80 | ALDH1A1 (0.41) | ALDH1A1KMT2AGPR35SMN1; SMN2RAB9A | |
| SCHEMBL11579652 | 0.78 | CYP1A2 (0.36) | ALDH1A1SMN1; SMN2RAB9ACYP1A2P2RX1 | |
| SCHEMBL11097728 | 0.78 | CYP1A2 (0.36) | KMT2AGPR35MAPTCYP1A2TSHR | |
| SCHEMBL11580765 | 0.78 | CYP1A2 (0.36) | CYP1A2CYP2D6ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446152-A | SUBSTITUTED PHENYLAMIDINOUREA | WILLIAM H. RORER, INC. (US) | 1984-05-01 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |