Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NMT2 | O60551 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MTTP | P55157 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17051234 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| Indecainide SCHEMBL121202 | 0.82 | KDM4E (0.42) | ALDH1A1KDM4EKMT2ATDP1 | |
| SCHEMBL11090876 | 0.81 | KDM4E (0.41) | ALDH1A1KDM4ETDP1MTTP | |
| Indecainide SCHEMBL11086669 | 0.81 | KDM4E (0.41) | ALDH1A1KDM4ETDP1MTTP | |
| Indecainide SCHEMBL121201 | 0.81 | KDM4E (0.41) | ALDH1A1KDM4ETDP1 | |
| Indecainide SCHEMBL29397898 | 0.81 | KDM4E (0.41) | ALDH1A1KDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL11090502 | 0.80 | KDM4E (0.41) | ALDH1A1KDM4ETDP1MTTP | |
| SCHEMBL11092008 | 0.80 | KDM4E (0.41) | ALDH1A1KDM4ETDP1MTTP | |
| Indecainide SCHEMBL1649456 | 0.80 | KDM4E (0.41) | ALDH1A1KDM4ETDP1MTTP | |
| SCHEMBL5863337 | 0.79 | GLA (0.40) | ALDH1A1MEN1KMT2AGLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452745-A | ANTIARRHYTHMIA AGENTS | ELI LILLY AND COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| US-4382093-A | 9-Aminoalkylfluorenes | ELI LILLY AND COMPANY (US) | 1983-05-03 | — | — | US | disclosed |
| US-4277495-A | FLUORENE 9-AMINOALKYL-9-CARBOXYLIC ACIDS OR ESTERS | ELI LILLY AND COMPANY (US) | 1981-07-07 | — | — | US | disclosed |
| EP-0018076-A1 | 9-Aminoalkylfluorenes, process therefor and antiarrhythmic formulations thereof | ELI LILLY AND COMPANY (US) | 1980-10-29 | — | — | EP | disclosed |