Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838201 | 0.87 | SLC6A4 (0.45) | SLC6A3SLC6A4ALDH1A1OPRM1GABRA1 | |
| SCHEMBL29457607 | 0.87 | SLC6A4 (0.45) | SLC6A3SLC6A4ALDH1A1OPRM1GABRA1 | |
| SCHEMBL17543073 | 0.86 | PSEN1 (0.42) | PDE4APDE4BPDE4CPDE4DOPRM1 | |
| SCHEMBL11468178 | 0.83 | SLC6A4 (0.50) | SLC6A3SLC6A4ALDH1A1OPRM1PDE7A | |
| SCHEMBL18742609 | 0.83 | SLC6A4 (0.46) | SLC6A3SLC6A4ALDH1A1OPRM1GABRA1 | |
| SCHEMBL8184370 | 0.82 | SLC6A4 (0.53) | SLC6A3SLC6A4ALDH1A1OPRM1PDE7A | |
| SCHEMBL2288498 | 0.81 | ADRA1A (0.42) | SLC6A4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28678474 | 0.79 | SLC6A4 (0.40) | SLC6A3SLC6A4ALDH1A1OPRM1SLC6A2 | |
| SCHEMBL6962020 | 0.79 | HTR2C (0.40) | SLC6A3SLC6A4ALDH1A1OPRM1SLC6A2 | |
| SCHEMBL11119613 | 0.79 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |