Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29457607 | 1.00 | SLC6A4 (0.45) | SLC6A4SLC6A3OPRM1TP53SLC6A2 | |
| SCHEMBL11468178 | 0.93 | SLC6A4 (0.50) | SLC6A4SLC6A3OPRM1TP53SLC6A2 | |
| SCHEMBL18742609 | 0.93 | SLC6A4 (0.46) | SLC6A4SLC6A3OPRM1TP53SLC6A2 | |
| SCHEMBL8184370 | 0.91 | SLC6A4 (0.53) | SLC6A4SLC6A3OPRM1SLC6A2ALDH1A1 | |
| SCHEMBL6962020 | 0.88 | HTR2C (0.40) | SLC6A4SLC6A3OPRM1SLC6A2ALDH1A1 | |
| SCHEMBL28678474 | 0.88 | SLC6A4 (0.40) | SLC6A4SLC6A3OPRM1SLC6A2ALDH1A1 | |
| SCHEMBL11093050 | 0.87 | SLC6A3 (0.39) | SLC6A4SLC6A3OPRM1SLC6A2ALDH1A1 | |
| SCHEMBL28691096 | 0.83 | OPRM1 (0.39) | SLC6A4SLC6A3OPRM1 | |
| SCHEMBL31454423 | 0.81 | OPRM1 (0.38) | SLC6A4SLC6A3OPRM1 | |
| SCHEMBL31459802 | 0.81 | HDAC6 (0.36) | SLC6A4SLC6A3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118239861-A | Preparation method of 1- (2, 4-dichlorophenyl) -1-cyclopropanecarbonitrile | 山东京博农化科技股份有限公司 | 2024-06-25 | — | — | CN | claimed |
| US-4859232-A | Substituted-aryl cyclopropanecarbonitriles and derivatives thereof as herbicide antidotes | MONSANTO COMPANY (US) | 1989-08-22 | — | — | US | claimed |
| EP-3710422-B1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY AND DIASTEREOMERICALLY ENRICHED CYCLOBUTANE AMINES AND AMIDES | SYNGENTA CROP PROTECTION AG (CH) | 2026-01-07 | — | — | EP | disclosed |
| CN-118239861-A | Preparation method of 1- (2, 4-dichlorophenyl) -1-cyclopropanecarbonitrile | 山东京博农化科技股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-118239861-A | Preparation method of 1- (2, 4-dichlorophenyl) -1-cyclopropanecarbonitrile | 山东京博农化科技股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-118239861-A | Preparation method of 1- (2, 4-dichlorophenyl) -1-cyclopropanecarbonitrile | 山东京博农化科技股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-114163382-B | Cyclobutanamide compound or salts and composition acceptable by pesticides and application thereof | 海利尔药业集团股份有限公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-111417618-B | Process for preparing enantiomerically and diastereomerically enriched cyclobutane amines and amides | 先正达参股股份有限公司 | 2023-06-30 | — | — | CN | disclosed |
| CN-114163382-A | Cyclobutanamide compound or salt thereof acceptable as pesticide, composition and application thereof | 海利尔药业集团股份有限公司 | 2022-03-11 | — | — | CN | disclosed |
| US-11053188-B2 | Process for the preparation of enantiomerically and diastereomerically enriched cyclobutane amines and amides | SYNGENTA PARTICIPATIONS AG (CH) | 2021-07-06 | — | — | US | disclosed |
| US-20200407311-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY AND DIASTEREOMERICALLY ENRICHED CYCLOBUTANE AMINES AND AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2020-12-31 | — | — | US | disclosed |
| EP-1960376-A1 | OXADIAZOLE DERIVATIVES WITH CRTH2 RECEPTOR ACTIVITY | 7TM Pharma A/S (DK) | 2008-08-27 | — | — | EP | disclosed |
| WO-2008061781-A1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO-DEGENERATIVE DISEASES | NV REMYND (BE) | 2008-05-29 | — | — | WO | disclosed |
| US-7297708-B2 | Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-11-20 | — | — | US | disclosed |
| US-7276526-B2 | Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-10-02 | — | — | US | disclosed |
| WO-2007090617-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV REMYND (BE) | 2007-08-16 | — | — | WO | disclosed |
| WO-2007062773-A1 | OXADIAZOLE DERIVATIVES WITH CRTH2 RECEPTOR ACTIVITY | 7TM PHARMA A/S (DK) | 2007-06-07 | — | — | WO | disclosed |
| US-20030229091-A1 | Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands | BRISTOL-MYERS SQUIBB COMPANY | 2003-12-11 | — | — | US | disclosed |
| US-20030114502-A1 | Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-06-19 | — | — | US | disclosed |
| US-4859232-A | Substituted-aryl cyclopropanecarbonitriles and derivatives thereof as herbicide antidotes | MONSANTO COMPANY (US) | 1989-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229091-A1 | Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands | CRHR1, CRH, CRHR2 | SLC6A4 404/4885SLC6A3 545/4885OPRM1 64/4885 |
| US-20030114502-A1 | Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands | CRH, CRHR1, CRHR2 | SLC6A4 349/4885SLC6A3 450/4885OPRM1 126/4885 |
| US-20200407311-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY AND DIASTEREOMERICALLY ENRICHED CYCLOBUTANE AMINES AND AMIDES | TBCB, ADORA2B, ADRA2B | SLC6A4 4213/4885SLC6A3 4715/4885OPRM1 2129/4885 |
| US-11053188-B2 | Process for the preparation of enantiomerically and diastereomerically enriched cyclobutane amines and amides | TBCB, ADORA2B, CCNB3 | SLC6A4 4283/4885SLC6A3 4636/4885OPRM1 2131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.